دورية أكاديمية

Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae

التفاصيل البيبلوغرافية
العنوان: Tissue adhesives for bacterial inhibition in extracorporeal membrane oxygenation cannulae
المؤلفون: India Pearse, Amanda Corley, Yue Qu, John Fraser
المصدر: Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-9 (2021)
بيانات النشر: SpringerOpen, 2021.
سنة النشر: 2021
المجموعة: LCC:Medical emergencies. Critical care. Intensive care. First aid
مصطلحات موضوعية: Extracorporeal membrane oxygenation, Infection, Cyanoacrylate, Tissue adhesive, Bacteria, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
الوصف: Abstract Background One of the most serious complications of extracorporeal membrane oxygenation (ECMO) therapy is ECMO cannulae infection, which can occur at quadruple the rate of central venous catheter infections, and significantly impact morbidity and paediatric mortality. The objective of this in vitro observational study was to assess antimicrobial properties of two n-butyl-2-octyl cyanoacrylate tissue adhesive (TA) formulations for bacterial inhibition at peripheral ECMO cannulae insertion sites. Methods Antimicrobial properties were assessed using modified agar disk-diffusion (n = 3) and simulated agar cannulation insertion site (n = 20) models. Both assays used Staphylococcus epidermidis which was seeded at the edge of the TA or dressing. Microorganism inhibition was visually inspected and evidenced by the presence or absence of a TA bacterial inhibition zone at 24 and 72 h. Results Both TAs provided effective barriers to bacterial migration under cannula dressings, to cannula insertion sites and down cannula tunnels. Additionally, both TAs demonstrated distinct zones of inhibition produced when left to polymerise onto agar plates seeded with S. epidermidis. Conclusions N-Butyl-2-octyl cyanoacrylate TA appears to inhibit bacterial growth and migration of S. epidermidis. Application of TA to cannulae insertion sites may therefore be a potential bedside strategy for infection prevention in ECMO cannulae, but requires further testing before being used clinically for this purpose.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2197-425X
Relation: https://doaj.org/toc/2197-425X
DOI: 10.1186/s40635-021-00388-6
URL الوصول: https://doaj.org/article/d5181952bc634a1c9295da8e51bbdbfa
رقم الأكسشن: edsdoj.5181952bc634a1c9295da8e51bbdbfa
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2197425X
DOI:10.1186/s40635-021-00388-6