دورية أكاديمية
Exosomes: biogenesis, biologic function and clinical potential
| العنوان: | Exosomes: biogenesis, biologic function and clinical potential |
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| المؤلفون: | Yuan Zhang, Yunfeng Liu, Haiying Liu, Wai Ho Tang |
| المصدر: | Cell & Bioscience, Vol 9, Iss 1, Pp 1-18 (2019) |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| المجموعة: | LCC:Biotechnology LCC:Biology (General) LCC:Biochemistry |
| مصطلحات موضوعية: | Exosome, Biogenesis, Biomarker, Therapeutic vehicle, Biotechnology, TP248.13-248.65, Biology (General), QH301-705.5, Biochemistry, QD415-436 |
| الوصف: | Abstract Exosomes are nano-sized biovesicles released into surrounding body fluids upon fusion of multivesicular bodies and the plasma membrane. They were shown to carry cell-specific cargos of proteins, lipids, and genetic materials, and can be selectively taken up by neighboring or distant cells far from their release, reprogramming the recipient cells upon their bioactive compounds. Therefore, the regulated formation of exosomes, specific makeup of their cargo, cell-targeting specificity are of immense biological interest considering extremely high potential of exosomes as non-invasive diagnostic biomarkers, as well as therapeutic nanocarriers. In present review, we outline and discuss recent progress in the elucidation of the regulatory mechanisms of exosome biogenesis, the molecular composition of exosomes, and technologies used in exosome research. Furthermore, we focus on the potential use of exosomes as valuable diagnostic and prognostic biomarkers for their cell-lineage and state-specific contents, and possibilities as therapeutic vehicles for drug and gene delivery. Exosome research is now in its infancy, in-depth understanding of subcellular components and mechanisms involved in exosome formation and specific cell-targeting will bring light on their physiological activities. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-3701 |
| Relation: | http://link.springer.com/article/10.1186/s13578-019-0282-2; https://doaj.org/toc/2045-3701 |
| DOI: | 10.1186/s13578-019-0282-2 |
| URL الوصول: | https://doaj.org/article/da51882df7154674bfb25b5c231e5d0f |
| رقم الأكسشن: | edsdoj.51882df7154674bfb25b5c231e5d0f |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20453701 |
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| DOI: | 10.1186/s13578-019-0282-2 |