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A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity

التفاصيل البيبلوغرافية
العنوان: A hexokinase isoenzyme switch in human liver cancer cells promotes lipogenesis and enhances innate immunity
المؤلفون: Laure Perrin-Cocon, Pierre-Olivier Vidalain, Clémence Jacquemin, Anne Aublin-Gex, Keedrian Olmstead, Baptiste Panthu, Gilles Jeans Philippe Rautureau, Patrice André, Piotr Nyczka, Marc-Thorsten Hütt, Nivea Amoedo, Rodrigue Rossignol, Fabian Volker Filipp, Vincent Lotteau, Olivier Diaz
المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Biology (General), QH301-705.5
الوصف: Many cancers fuel their rapid growth by replacing glucokinase with its higher affinity isoenzyme, hexokinase 2 (HK2), making HK2 an attractive drug target. In this study, Perrin-Cocon and Vidalain et al. use CRISPR/Cas-9 gene editing to reverse this enzymatic switch in human liver cancer cells, and find this restores innate immune function as well as reversing cancer-associated metabolic reprogramming.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2399-3642
Relation: https://doaj.org/toc/2399-3642
DOI: 10.1038/s42003-021-01749-3
URL الوصول: https://doaj.org/article/a519b0af2fba49868394944910f843d0
رقم الأكسشن: edsdoj.519b0af2fba49868394944910f843d0
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23993642
DOI:10.1038/s42003-021-01749-3