دورية أكاديمية
Identification and validation of molecular subtype and prognostic signature for lung adenocarcinoma based on neutrophil extracellular traps
| العنوان: | Identification and validation of molecular subtype and prognostic signature for lung adenocarcinoma based on neutrophil extracellular traps |
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| المؤلفون: | Yanhua Zuo, Guangyi Leng, Ping Leng |
| المصدر: | Pathology and Oncology Research, Vol 29 (2023) |
| بيانات النشر: | Frontiers Media S.A., 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens LCC:Pathology |
| مصطلحات موضوعية: | immunotherapy, lung adenocarcinoma, tumor microenvironment, prognostic signature, neutrophil extracellular traps, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282, Pathology, RB1-214 |
| الوصف: | Background: Neutrophil Extracellular Traps (NETs) are fibrous networks made of DNA-histone complexes and proteins protruded from activated neutrophils. Accumulating evidences have highlighted the vital role of NETs in tumor progression and diffusion. However, limited systematic studies regarding the role of NETs in LUAD have been performed.Methods: Differentially expressed NETs-related genes and their mutation landscape were identified with TCGA database. Consensus clustering analysis was performed to determine the NETs-related subtypes of LUAD. LASSO algorithm was employed to construct a prognostic signature. Moreover, GSE30219 and GSE31210 were used as independent validation. We also constructed a lncRNA-miRNA-mRNA regulatory axis with several miRNA and lncRNA databases.Results: Consensus clustering identified two NETs-related clusters in LUAD. High NETs score was correlated with a favorable overall survival, abundant immune cell infiltration, and high activity of immune response signal pathways. Six NET-related genes (G0S2, KCNJ15, S100A12, AKT2, CTSG, and HMGB1) with significant prognostic value were screened to develop a prognostic signature. LUAD patients with low-risk had a significantly favorable overall survival both in the training set and validation set. Moreover, NETs-related risk score and clinical stage could act as an independent prognostic factor for LUAD patients. Significant correlation was obtained between risk score and tumor immune microenvironment. We also identified lncRNA BCYRN1/miR-3664-5p/CTSG regulatory axis that may be involved in the progression of LUAD.Conclusion: We developed two molecular subtypes and a prognostic signature for LUAD based on NETs-related genes. This stratification could provide more evidences for estimating the prognosis and immunotherapy of LAUD patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1532-2807 |
| Relation: | https://www.por-journal.com/articles/10.3389/pore.2023.1610899/full; https://doaj.org/toc/1532-2807 |
| DOI: | 10.3389/pore.2023.1610899 |
| URL الوصول: | https://doaj.org/article/51bdb3d9781f49c7b2f71525c1cd10bd |
| رقم الأكسشن: | edsdoj.51bdb3d9781f49c7b2f71525c1cd10bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 15322807 |
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| DOI: | 10.3389/pore.2023.1610899 |