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Identification of Candidate Genes for Economically Important Carcass Cutting in Commercial Pigs through GWAS

التفاصيل البيبلوغرافية
العنوان: Identification of Candidate Genes for Economically Important Carcass Cutting in Commercial Pigs through GWAS
المؤلفون: Fuchen Zhou, Jianping Quan, Donglin Ruan, Yibin Qiu, Rongrong Ding, Cineng Xu, Yong Ye, Gengyuan Cai, Langqing Liu, Zebin Zhang, Jie Yang, Zhenfang Wu, Enqin Zheng
المصدر: Animals, Vol 13, Iss 20, p 3243 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Veterinary medicine
LCC:Zoology
مصطلحات موضوعية: pigs, fine segmentation, tenderloin weight, rib weight, genome-wide association studies, Veterinary medicine, SF600-1100, Zoology, QL1-991
الوصف: During the process of pork production, the carcasses of pigs are divided and sold, which provides better economic benefits and market competitiveness for pork production than selling the carcass as a whole. Due to the significant cost of post-slaughter phenotypic measurement, the genetic architecture of tenderloin weight (TLNW) and rib weight (RIBW)—important components of pig carcass economic value—remain unknown. In this study, we conducted genome-wide association studies (GWAS) for TLNW and RIBW traits in a population of 431 Duroc × Landrace × Yorkshire (DLY) pigs. In our study, the most significant single nucleotide polymorphism (SNP) associated with TLNW was identified as ASGA0085853 (3.28 Mb) on Sus scrofa chromosome 12 (SSC12), while for RIBW, it was Affx-1115046258 (172.45 Mb) on SSC13. Through haplotype block analysis, we discovered a novel quantitative trait locus (QTL) associated with TLNW, spanning a 5 kb region on SSC12, and a novel RIBW-associated QTL spanning 1.42 Mb on SSC13. Furthermore, we hypothesized that three candidate genes, TIMP2 and EML1, and SMN1, are associated with TLNW and RIBW, respectively. Our research not only addresses the knowledge gap regarding TLNW, but also serves as a valuable reference for studying RIBW. The identified SNP loci strongly associated with TLNW and RIBW may prove useful for marker-assisted selection in pig breeding programs.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-2615
Relation: https://www.mdpi.com/2076-2615/13/20/3243; https://doaj.org/toc/2076-2615
DOI: 10.3390/ani13203243
URL الوصول: https://doaj.org/article/5260b053425d4edaba3743288bea372b
رقم الأكسشن: edsdoj.5260b053425d4edaba3743288bea372b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20762615
DOI:10.3390/ani13203243