دورية أكاديمية
Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy
| العنوان: | Carborane Polypeptide Derivatives for Boron Neutron Capture Therapy |
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| المؤلفون: | HAN Yi, LI Feng-lin, LUO Zhi-fu |
| المصدر: | He huaxue yu fangshe huaxue, Vol 45, Iss 6, Pp 524-531 (2023) |
| بيانات النشر: | Editorial Office of Journal of Nuclear and Radiochemistry, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Nuclear engineering. Atomic power LCC:Chemical technology |
| مصطلحات موضوعية: | carborane polypeptide derivatives, bnct, targeted therapy, Nuclear engineering. Atomic power, TK9001-9401, Chemical technology, TP1-1185 |
| الوصف: | The design and application of carborane polypeptide derivatives have attracted more and more attention, especially as boron carrier in the treatment of malignant tumors(BNCT). BNCT uses 10B to react with neutron capture, releasing alpha particles that kill tumor cells. As a binary targeted therapy, the key to its success is the targeting and affinity effect of boron carriers. At present, how to design more efficient boron carriers is the main problem in the development of BNCT. Polypeptides, as biological essential substances, can be taken up specifically by tumors while increasing the targeting of their derivatives, which is a great advantage of carbborane polypeptide compounds as boron carriers. In this paper, the reported carbborane polypeptide derivatives are classified and summarized for the first time, and the development potential as boron carriers for neutron capture therapy is evaluated. The summary of carbborane containing polypeptide derivatives will provide research impetus for the development of a new generation of boron carriers designed for neutron capture therapy. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Chinese |
| تدمد: | 0253-9950 |
| Relation: | http://www.jnrc.org.cn/CN/10.7538/hhx.2023.45.06.0524; https://doaj.org/toc/0253-9950 |
| DOI: | 10.7538/hhx.2023.45.06.0524 |
| URL الوصول: | https://doaj.org/article/52774a5dc23b470e8ba55356190963a1 |
| رقم الأكسشن: | edsdoj.52774a5dc23b470e8ba55356190963a1 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02539950 |
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| DOI: | 10.7538/hhx.2023.45.06.0524 |