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A review of in vivo and in vitro aspects of alcohol-induced dose dumping

التفاصيل البيبلوغرافية
العنوان: A review of in vivo and in vitro aspects of alcohol-induced dose dumping
المؤلفون: Susan D’Souza, Stephen Mayock, Alger Salt
المصدر: AAPS Open, Vol 3, Iss 1, Pp 1-20 (2017)
بيانات النشر: SpringerOpen, 2017.
سنة النشر: 2017
المجموعة: LCC:Therapeutics. Pharmacology
LCC:Pharmacy and materia medica
مصطلحات موضوعية: Alcohol induced dose dumping (AIDD), In vitro, In vivo, Regulatory, Opioids, Centrally acting drugs, Therapeutics. Pharmacology, RM1-950, Pharmacy and materia medica, RS1-441
الوصف: Abstract This review provides a comprehensive list of in vivo and in vitro studies that have investigated alcohol induced dose dumping (AIDD) in modified release dosage forms. Of the numerous classes of drugs commercially available as modified release products, opioids, centrally acting drugs, and drugs with a narrow therapeutic index present high risks from dose dumping, despite being formulated in a manner that releases drug in a tailored or delayed fashion. Awareness of AIDD has led to the withdrawal of a few marketed products by Regulatory Agencies, and black box warnings on others. Since then, significant effort has focused on proving the robustness of a formulation when co-ingested with alcohol. Patient risk is deemed to be low if the formulation and its performance is unimpaired by the presence of 0–40% alcohol under in vivo and in vitro conditions.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2364-9534
Relation: http://link.springer.com/article/10.1186/s41120-017-0014-9; https://doaj.org/toc/2364-9534
DOI: 10.1186/s41120-017-0014-9
URL الوصول: https://doaj.org/article/52d6414477bd4595aa7de045c8ea834a
رقم الأكسشن: edsdoj.52d6414477bd4595aa7de045c8ea834a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23649534
DOI:10.1186/s41120-017-0014-9