دورية أكاديمية
أعرض في EDS

Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition

التفاصيل البيبلوغرافية
العنوان: Longitudinal analysis of Plasmodium sporozoite motility in the dermis reveals component of blood vessel recognition
المؤلفون: Christine S Hopp, Kevin Chiou, Daniel RT Ragheb, Ahmed M Salman, Shahid M Khan, Andrea J Liu, Photini Sinnis
المصدر: eLife, Vol 4 (2015)
بيانات النشر: eLife Sciences Publications Ltd, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine
LCC:Science
LCC:Biology (General)
مصطلحات موضوعية: malaria, sporozoite, gliding motility, skin, Plasmodium, Medicine, Science, Biology (General), QH301-705.5
الوصف: Malaria infection starts with injection of Plasmodium sporozoites by an Anopheles mosquito into the skin of the mammalian host. How sporozoites locate and enter a blood vessel is a critical, but poorly understood process. In this study, we examine sporozoite motility and their interaction with dermal blood vessels, using intravital microscopy in mice. Our data suggest that sporozoites exhibit two types of motility: in regions far from blood vessels, they exhibit ‘avascular motility’, defined by high speed and less confinement, while in the vicinity of blood vessels their motility is more constrained. We find that curvature of sporozoite tracks engaging with vasculature optimizes contact with dermal capillaries. Imaging of sporozoites with mutations in key adhesive proteins highlight the importance of the sporozoite's gliding speed and its ability to modulate adhesive properties for successful exit from the inoculation site.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2050-084X
Relation: https://elifesciences.org/articles/07789; https://doaj.org/toc/2050-084X
DOI: 10.7554/eLife.07789
URL الوصول: https://doaj.org/article/e5315d0166d4463aadcec26539cc4148
رقم الأكسشن: edsdoj.5315d0166d4463aadcec26539cc4148
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2050084X
DOI:10.7554/eLife.07789