دورية أكاديمية

Continuous Time-Domain Cerebrovascular Reactivity Metrics and Discriminate Capacity for the Upper and Lower Limits of Autoregulation: A Scoping Review of the Animal Literature

التفاصيل البيبلوغرافية
العنوان: Continuous Time-Domain Cerebrovascular Reactivity Metrics and Discriminate Capacity for the Upper and Lower Limits of Autoregulation: A Scoping Review of the Animal Literature
المؤلفون: Amanjyot Singh Sainbhi, Logan Froese, Alwyn Gomez, Carleen Batson, Kevin Y. Stein, Arsalan Alizadeh, Frederick A. Zeiler
المصدر: Neurotrauma Reports, Vol 2, Iss 1, Pp 639-659 (2021)
بيانات النشر: Mary Ann Liebert, 2021.
سنة النشر: 2021
المجموعة: LCC:Medical emergencies. Critical care. Intensive care. First aid
مصطلحات موضوعية: cerebrovascular autoregulation, cerebrovascular reactivity metrics, Lassen autoregulatory curve, lower limit of autoregulation, time-domain metrics, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
الوصف: Over a wide range of systemic arterial pressures, cerebral blood flow (CBF) is regulated fairly constantly by the cerebral vessels in a process termed cerebral autoregulation (CA), which is depicted by the Lassen autoregulatory curve. After traumatic brain injury (TBI), CA can get impaired and these impairments manifest in changes of the Lassen autoregulatory curve. Continuous surrogate metrics of pressure-based CA, termed cerebrovascular reactivity (CVR) metrics, evaluate the relationship between slow vasogenic fluctuations in a driving pressure for cerebral blood flow, and the most commonly studied and utilized measures are based in the time domain and have been increasingly applied in bedside TBI care and have sparked the investigation of individualized cerebral perfusion pressure targets. However, not all CVR metrics have been validated as true measures of autoregulation in the pre-clinical setting. We reviewed all available pre-clinical animal literature that assessed the association between continuous time-domain metrics of CVR and some aspect of the Lassen autoregulatory curve. All 15 articles found associated the evaluated continuous metrics to the lower limit of autoregulation curve whereas none looked at the upper limit. Most of the evaluated metrics showed the ability to discriminate the lower limit of autoregulation with various methods of perturbation. Further work is required to evaluate the utility of such surrogate measures against the upper limit of autoregulation, while also providing validation to the existing literature supporting specific indices and their ability to discriminate the lower limit.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2689-288X
Relation: https://doaj.org/toc/2689-288X
DOI: 10.1089/NEUR.2021.0043
URL الوصول: https://doaj.org/article/531b7a841b144044bdcf1c8e8c6adde2
رقم الأكسشن: edsdoj.531b7a841b144044bdcf1c8e8c6adde2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2689288X
DOI:10.1089/NEUR.2021.0043