دورية أكاديمية
Head and Neck Paragangliomas: Patterns of Otolaryngology Referrals for Genetic Testing Over 2 Decades
| العنوان: | Head and Neck Paragangliomas: Patterns of Otolaryngology Referrals for Genetic Testing Over 2 Decades |
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| المؤلفون: | Joshua D. Smith MD, Emily L. Bellile MS, Tobias Else MD, Gregory Basura MD, PhD |
| المصدر: | OTO Open, Vol 5 (2021) |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Otorhinolaryngology LCC:Surgery |
| مصطلحات موضوعية: | Otorhinolaryngology, RF1-547, Surgery, RD1-811 |
| الوصف: | Objective A large proportion of head and neck paragangliomas (HNPGLs) arise in patients with a genetic predisposition due to pathogenic variants in succinate dehydrogenase ( SDHx ) genes. Contemporary practice guidelines recommend consideration of referral for genetic testing for all patients with HNPGLs. We sought to assess adherence to these recommendations, factors associated with referral, and temporal trends in referral patterns by otolaryngologists over the past 2 decades. Study Design Retrospective cohort study. Setting Single tertiary care center. Methods All patients with newly diagnosed HNPGLs treated at a single academic center between 2000 and 2019 were included. Bivariable association of specific features of referral for genetic testing by treating surgeons were tested with χ 2 and Wilcoxon rank-sum tests. Logistic regression was used to assess temporal trends in referral patterns overall and for specific clinical subgroups over time. Results Of 221 patients included, only 77 (34.8%) were referred for genetic testing. Factors associated with referral included young age, family history of paraganglioma, more recent year of diagnosis (ie, closer to study end date), tumor subsite (all P < .0001), and treatment by an otolaryngologist (vs vascular surgeon or neurosurgeon, P = .009). Overall, referral rates increased over time ( P = .0002), but even in the most recent 5 years, only 51% of newly diagnosed patients were referred. Conclusion Our analysis suggests that referral rates for genetic testing in patients with HNPGLs are growing yet are still largely based on young age, family history, and tumor subsite. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2473-974X 2473974X |
| Relation: | https://doaj.org/toc/2473-974X |
| DOI: | 10.1177/2473974X21995453 |
| URL الوصول: | https://doaj.org/article/53582a5091e44f6cb192274ea4ef67ba |
| رقم الأكسشن: | edsdoj.53582a5091e44f6cb192274ea4ef67ba |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 2473974X |
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| DOI: | 10.1177/2473974X21995453 |