دورية أكاديمية
The Efficacy of Ramucirumab in the Treatment of Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis of RCTs
| العنوان: | The Efficacy of Ramucirumab in the Treatment of Gastric or Gastroesophageal Junction Cancer: A Meta-Analysis of RCTs |
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| المؤلفون: | Hongqiong Yang, Yaojun Zhou, Liangzhi Wang, Tianyi Gu, Mengjia Lv, Jinling Sun, Chao Tu, Junbo He |
| المصدر: | Gastroenterology Research and Practice, Vol 2021 (2021) |
| بيانات النشر: | Hindawi Limited, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Diseases of the digestive system. Gastroenterology |
| مصطلحات موضوعية: | Diseases of the digestive system. Gastroenterology, RC799-869 |
| الوصف: | Five electronic databases were searched for eligible records. Outcomes were presented and analyzed according to the objective response rate (ORR), progression-free survival (PFS) rate, and overall survival (OS) rate. Five records involving 2,024 participants were included in the study. The pooled analysis of OS and PFS were longer with ramucirumab (RAM) therapy than without RAM for OS (odds ratio OR=0.90, 95% confidence interval CI=0.82–1.00, p=0.05) and PFS (OR=0.74, 95%CI=0.57–0.96, p=0.02). Moreover, compared with the current first-line chemotherapy, the OS (OR=0.93, 95%CI=0.83–1.04, p=0.19) and PFS (OR=0.82, 95%CI=0.64–1.06, p=0.13) results were not significantly higher with RAM. The ORRs of the patients in the RAM therapy groups were significantly higher than those in the groups without RAM (OR=1.40, 95%CI=1.14–1.73, p=0.001). |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1687-6121 1687-630X |
| Relation: | https://doaj.org/toc/1687-6121; https://doaj.org/toc/1687-630X |
| DOI: | 10.1155/2021/8960315 |
| URL الوصول: | https://doaj.org/article/53665f51cc41439884fdccaacb40f147 |
| رقم الأكسشن: | edsdoj.53665f51cc41439884fdccaacb40f147 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16876121 1687630X |
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| DOI: | 10.1155/2021/8960315 |