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Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation.

التفاصيل البيبلوغرافية
العنوان: Reversible plasticity of fear memory-encoding amygdala synaptic circuits even after fear memory consolidation.
المؤلفون: Ingie Hong, Jihye Kim, Junuk Lee, Sungmo Park, Beomjong Song, Jeongyeon Kim, Bobae An, Kyungjoon Park, Hyun Woo Lee, Seungbok Lee, Hyun Kim, Sang-Hyun Park, Khee Dong Eom, Sukwon Lee, Sukwoo Choi
المصدر: PLoS ONE, Vol 6, Iss 9, p e24260 (2011)
بيانات النشر: Public Library of Science (PLoS), 2011.
سنة النشر: 2011
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: It is generally believed that after memory consolidation, memory-encoding synaptic circuits are persistently modified and become less plastic. This, however, may hinder the remaining capacity of information storage in a given neural circuit. Here we consider the hypothesis that memory-encoding synaptic circuits still retain reversible plasticity even after memory consolidation. To test this, we employed a protocol of auditory fear conditioning which recruited the vast majority of the thalamic input synaptic circuit to the lateral amygdala (T-LA synaptic circuit; a storage site for fear memory) with fear conditioning-induced synaptic plasticity. Subsequently the fear memory-encoding synaptic circuits were challenged with fear extinction and re-conditioning to determine whether these circuits exhibit reversible plasticity. We found that fear memory-encoding T-LA synaptic circuit exhibited dynamic efficacy changes in tight correlation with fear memory strength even after fear memory consolidation. Initial conditioning or re-conditioning brought T-LA synaptic circuit near the ceiling of their modification range (occluding LTP and enhancing depotentiation in brain slices prepared from conditioned or re-conditioned rats), while extinction reversed this change (reinstating LTP and occluding depotentiation in brain slices prepared from extinguished rats). Consistently, fear conditioning-induced synaptic potentiation at T-LA synapses was functionally reversed by extinction and reinstated by subsequent re-conditioning. These results suggest reversible plasticity of fear memory-encoding circuits even after fear memory consolidation. This reversible plasticity of memory-encoding synapses may be involved in updating the contents of original memory even after memory consolidation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3176280?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0024260
URL الوصول: https://doaj.org/article/53e43193ca804a119502f11558205834
رقم الأكسشن: edsdoj.53e43193ca804a119502f11558205834
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0024260