دورية أكاديمية
Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C
العنوان: | Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C |
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المؤلفون: | Zunqiang Yan, Lijuan Cai, Xiaoyu Huang, Wenyang Sun, Shouhu Li, Pengfei Wang, Qiaoli Yang, Tiantuan Jiang, Shuangbao Gun |
المصدر: | Animals, Vol 9, Iss 5, p 269 (2019) |
بيانات النشر: | MDPI AG, 2019. |
سنة النشر: | 2019 |
المجموعة: | LCC:Veterinary medicine LCC:Zoology |
مصطلحات موضوعية: | Ileum, Pig, Clostridium perfringens type C, Diarrhea, Veterinary medicine, SF600-1100, Zoology, QL1-991 |
الوصف: | C. perfringens type C can induce enteritis accompanied by diarrhea and annually causes significant economic losses to the global pig industry. The pathogenic mechanisms of C. perfringens type C in pigs are still largely unknown. To investigate this, we challenged seven-day-old piglets with C. perfringens type C to cause diarrhea. We performed hematoxylin & eosin (H&E) staining of the small intestine (including duodenum, jejunum, and ileum) and assessed gene expression in the ileal tissue. H&E staining of the duodenum, jejunum, and ileum demonstrated inflammation and edema of the lamina propria and submucosa. A total of 2181 differentially expressed genes (DEGs) were obtained in ileal tissues. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis of DEGs indicated that the main pathways were enriched in the T cell receptor signaling pathway, NF-kappa B signaling pathway, and (tumor necrosis factor) TNF signaling pathway. These results provide insights into the pathogenicity of C. perfringens type C and improve our understanding of host−bacteria interactions. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2076-2615 |
Relation: | https://www.mdpi.com/2076-2615/9/5/269; https://doaj.org/toc/2076-2615 |
DOI: | 10.3390/ani9050269 |
URL الوصول: | https://doaj.org/article/54001dd41b834a66b556211e1a65a787 |
رقم الأكسشن: | edsdoj.54001dd41b834a66b556211e1a65a787 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 20762615 |
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DOI: | 10.3390/ani9050269 |