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Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C

التفاصيل البيبلوغرافية
العنوان: Histological and Comparative Transcriptome Analyses Provide Insights into Small Intestine Health in Diarrheal Piglets after Infection with Clostridium Perfringens Type C
المؤلفون: Zunqiang Yan, Lijuan Cai, Xiaoyu Huang, Wenyang Sun, Shouhu Li, Pengfei Wang, Qiaoli Yang, Tiantuan Jiang, Shuangbao Gun
المصدر: Animals, Vol 9, Iss 5, p 269 (2019)
بيانات النشر: MDPI AG, 2019.
سنة النشر: 2019
المجموعة: LCC:Veterinary medicine
LCC:Zoology
مصطلحات موضوعية: Ileum, Pig, Clostridium perfringens type C, Diarrhea, Veterinary medicine, SF600-1100, Zoology, QL1-991
الوصف: C. perfringens type C can induce enteritis accompanied by diarrhea and annually causes significant economic losses to the global pig industry. The pathogenic mechanisms of C. perfringens type C in pigs are still largely unknown. To investigate this, we challenged seven-day-old piglets with C. perfringens type C to cause diarrhea. We performed hematoxylin & eosin (H&E) staining of the small intestine (including duodenum, jejunum, and ileum) and assessed gene expression in the ileal tissue. H&E staining of the duodenum, jejunum, and ileum demonstrated inflammation and edema of the lamina propria and submucosa. A total of 2181 differentially expressed genes (DEGs) were obtained in ileal tissues. Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis of DEGs indicated that the main pathways were enriched in the T cell receptor signaling pathway, NF-kappa B signaling pathway, and (tumor necrosis factor) TNF signaling pathway. These results provide insights into the pathogenicity of C. perfringens type C and improve our understanding of host−bacteria interactions.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2076-2615
Relation: https://www.mdpi.com/2076-2615/9/5/269; https://doaj.org/toc/2076-2615
DOI: 10.3390/ani9050269
URL الوصول: https://doaj.org/article/54001dd41b834a66b556211e1a65a787
رقم الأكسشن: edsdoj.54001dd41b834a66b556211e1a65a787
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20762615
DOI:10.3390/ani9050269