دورية أكاديمية
FOXD1 expression-based prognostic model for uveal melanoma
| العنوان: | FOXD1 expression-based prognostic model for uveal melanoma |
|---|---|
| المؤلفون: | Yang Luo, Renhao Ni, Xiaojun Jin, Peipei Feng, Chenyi Dai, Lingjing Jiang, Pingping Chen, Lu Yang, Yabin Zhu |
| المصدر: | Heliyon, Vol 9, Iss 11, Pp e21333- (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science (General) LCC:Social sciences (General) |
| مصطلحات موضوعية: | FOXD1, Uveal melanoma, Patient survival, Treatment sensitivity, Prognostic model, Science (General), Q1-390, Social sciences (General), H1-99 |
| الوصف: | FOXD1, a new member of the FOX transcription factor family, serves as a mediator and biomarker for cell reprogramming. But its contribution to prognosis of uveal melanoma (UVM) is unclear. This study demonstrated that FOXD1 might promote tumor growth and invasion, because FOXD1 expression was negatively correlated with overall survival, progression-free survival, and disease-specific survival in UVM patients. This conjecture was verified in cell culture with human uveal melanoma cell line (MUM2B) as model cells. Additionally, the biological mechanisms of FOXD1 based on FOXD1-related genomic spectrum, molecular pathways, tumor microenvironment, and drug treatment sensitivity were examined using The Cancer Genome Atlas (TCGA) database, aiming to reasonably explain why FOXD1 leads to poor prognosis of UVM. On these bases, a novel tumor prognostic model was established using the FOXD1-related immunomodulators TMEM173, TNFRSF4, TNFSF13, and ULBP1, which will enable the stratification of disease seriousness and clinical treatment for patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844023085419; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2023.e21333 |
| URL الوصول: | https://doaj.org/article/540dacd658fd4e54b41d5e39603a17fa |
| رقم الأكسشن: | edsdoj.540dacd658fd4e54b41d5e39603a17fa |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24058440 |
|---|---|
| DOI: | 10.1016/j.heliyon.2023.e21333 |