Charcot neuroarthropathy of the foot and ankle is a destructive disorder resulting in severe and debilitating deformity. The goal of surgical reconstruction in Charcot neuroarthropathy is to create a stable, plantigrade foot that is amenable to bracing and offloading. Many reconstruction methods have been described in the literature including ostectomy of osseous prominences, realignment ostoeotmies, intramedullary midfoot beaming, plate fixation and external fixation. In this study we describe the use of tibiotalocalcaneal arthrodesis with intramedullary nail fixation for the treatment of midfoot Charcot neuroarthropathy in 12 consecutive patients. The mean age of our patient population was 61.33 years, mean BMI was 37.03 kg/m2, 9 patients were type II diabetics, 2 patients were type I diabetics and 1 patient had a diagnosis of idiopathic neuropathy without underlying diabetes mellitus (DM). The mean duration of DM diagnosis was 24.73 years. 9 patients within the study population had suffered from chronic or recurrent ulcerations secondary to osseous deformity that had failed conservative treatment and 3 patients had residual ulceration at the time of surgery. Fusion was observed in 10 of 12 patients within the study. All patients had a functional, plantigrade foot post-operatively. Overall, 5 patients are ambulating in custom diabetic shoes without assistive devices while the remaining patients are ambulating with assistive devices. The results of this study indicate that tibiotalocalcaneal arthrodesis with retrograde intramedullary nail fixation for midfoot Charcot neuroarthropathy is a reliable treatment option to provide a stable, plantigrade, braceable foot.