دورية أكاديمية
Tailoring the Surface Chemistry of PEDOT:PSS to Promote Supported Lipid Bilayer Formation
| العنوان: | Tailoring the Surface Chemistry of PEDOT:PSS to Promote Supported Lipid Bilayer Formation |
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| المؤلفون: | Konstantinos Kallitsis, Anna‐Maria Pappa, Zixuan Lu, Alberto Alvarez‐Fernandez, Ioanna Charalambous, Sina Schack, Walther C. Traberg, Quentin Thiburce, Karan Bali, Graham Christie, Stefan Guldin, Susan Daniel, Alberto Salleo, Róisín M. Owens |
| المصدر: | Macromolecular Materials and Engineering, Vol 308, Iss 9, Pp n/a-n/a (2023) |
| بيانات النشر: | Wiley-VCH, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Materials of engineering and construction. Mechanics of materials LCC:Engineering (General). Civil engineering (General) |
| مصطلحات موضوعية: | conducting polymers, supported lipid bilayers, organic bioelectronics, surface functionalization, virus detection, Materials of engineering and construction. Mechanics of materials, TA401-492, Engineering (General). Civil engineering (General), TA1-2040 |
| الوصف: | Abstract This communication reports on a versatile and substrate‐agnostic method to tune the surface chemistry of conducting polymers with the aim of bridging the chemical mismatch between bioelectronic devices and biological systems. As a proof of concept, the surface of poly(3,4‐ethylenedioxythiophene) polystyrene sulfonate (PEDOT:PSS) is grafted with a short‐chain oligoethylene glycol monolayer to favor the formation of cell‐derived supported lipid bilayers (SLBs). This method is tuned to optimize the affinity between the supported lipid bilayer and the conducting polymer, leading to significant improvements in bilayer quality and therefore electronic readouts. To validate the impact of surface functionalization on the system's ability to transduce biological phenomena into quantifiable electronic signals, the activity of a virus commonly used as a surrogate for SARS‐CoV‐2 (mouse hepatitis virus) is monitored with and without surface treatment. The functionalized devices exhibit significant improvements in electronic output, stemming from the improved SLB quality, therefore strengthening the case for the use of such an approach in membrane‐on‐a‐chip systems. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1439-2054 1438-7492 |
| Relation: | https://doaj.org/toc/1438-7492; https://doaj.org/toc/1439-2054 |
| DOI: | 10.1002/mame.202300038 |
| URL الوصول: | https://doaj.org/article/5432bcfec1fe4c8aac66d957bb154020 |
| رقم الأكسشن: | edsdoj.5432bcfec1fe4c8aac66d957bb154020 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14392054 14387492 |
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| DOI: | 10.1002/mame.202300038 |