دورية أكاديمية
Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review
| العنوان: | Beneficial Effects of Statins on Seizures Independent of Their Lipid-Lowering Effect: A Narrative Review |
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| المؤلفون: | Arash Amanlou, Ehsan Nassireslami, Ahmad Reza Dehpour, Amir Rashidian, Mohsen Chamanara |
| المصدر: | Iranian Journal of Medical Sciences, Vol 48, Iss 1, Pp 13-25 (2023) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | hydroxymethylglutaryl-coa reductase inhibitors, hmg-coa, statins, seizures, epilepsy, Medicine (General), R5-920 |
| الوصف: | Among the many types of central nervous system (CNS) disorders, seizures and epilepsy severely affect the quality of life and routine daily activity of the sufferers. We aimed to review research studies that investigated the effect of statins on the prevention and treatment of seizures and epilepsy. Both animal models and human studies were included in this review. This article starts with a brief introduction about seizure, its prevalence, treatment, and various animal models of seizures and epilepsy. Next, we discuss statin’s mechanism of action, side effects, and effects on neurological disorders with a specific focus on seizures. Finally, the effects of different types of statins on seizures are compared. The present review gives a better understanding of the therapeutic effects of statins on neurological disorders in animal models and human studies. This permits researchers to set up study designs to resolve current ambiguities and contradictions on the beneficial effects of statins on neurological disorders. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0253-0716 1735-3688 |
| Relation: | https://ijms.sums.ac.ir/article_48599_4be761ca5ff53a2303c615e6f8467475.pdf; https://doaj.org/toc/0253-0716; https://doaj.org/toc/1735-3688 |
| DOI: | 10.30476/ijms.2021.91645.2289 |
| URL الوصول: | https://doaj.org/article/a54d2b43c54d4786a0da63c5a3ab2bda |
| رقم الأكسشن: | edsdoj.54d2b43c54d4786a0da63c5a3ab2bda |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 02530716 17353688 |
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| DOI: | 10.30476/ijms.2021.91645.2289 |