دورية أكاديمية
Relation of polymorphisms VEGF (+405G>C) and TNFα (-308A>G) with the embryo implantation in Cubans patient undergoing in vitro fertilization
| العنوان: | Relation of polymorphisms VEGF (+405G>C) and TNFα (-308A>G) with the embryo implantation in Cubans patient undergoing in vitro fertilization |
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| المؤلفون: | Francisco Sotomayor Lugo, Beatriz Marcheco Teruel, Kenia Rodríguez Martínez, Alejandro Esperón Álvarez, Ahmed Menocal Alayón, José Alberto Almaguer Almaguer, Ixchel López Reyes, Rosa María Flores Sánchez, Yoandra Crespo Ferrán, Vivian Veiga Loyola |
| المصدر: | Revista Cubana de Investigaciones Biomédicas, Vol 38, Iss 5 (2020) |
| بيانات النشر: | Centro Nacional de Información de Ciencias Médicas. Editorial de Ciencias Médicas (ECIMED), 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | assisted reproduction, in vitro fertilization, vegf, tnfα, Medicine (General), R5-920 |
| الوصف: | Introduction. A cohort study was carried out at the National Center for Medical Genetics, from July 2017 to June 2018, in 27 patients evaluated in the consultation for the infertile couple at the Hermanos Ameijeiras Hospital. Objective. To establish the relationship of the individual and combined expression of the genotypes of the polymorphisms VEGF (+405 G> C) and TNFα (-308A> G), with the rates of embryo implantation in Cuban patients receiving treatment with in vitro fertilization. Materials and Methods.The identification of the genotypes was carried out using an ARMS PCR. The Hardy-Weinberg equilibrium was determined by applying the Chi square test of goodness of fit from a reference population, and a Principal Component Analysis (PCA) was carried out to evaluate the genotypic population structure with respect to the variables studied. Results. Individuals with combined genotype variant VEGF.CC / TNFα.GG were grouped homogeneously in the PCA model with respect to axis 2, where there was a higher frequency of women with a low implantation rate. In contrast, patients with a genotypic TNFα.AG variant were grouped according to the highest implantation rates. Conclusions. It was concluded that there is a relationship between genotype variants VEGF.CC and TNFα.GG with a low implantation rate, when they are expressed individually or in combination in patients treated with the in vitro fertilization technique, while the individual genotypic variant TNFα. AG is associated with a higher implantation rate. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Spanish; Castilian |
| تدمد: | 0864-0300 1561-3011 |
| Relation: | http://www.revibiomedica.sld.cu/index.php/ibi/article/view/443; https://doaj.org/toc/0864-0300; https://doaj.org/toc/1561-3011 |
| URL الوصول: | https://doaj.org/article/c54e34d266fb443eb28e817e237a6b7c |
| رقم الأكسشن: | edsdoj.54e34d266fb443eb28e817e237a6b7c |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 08640300 15613011 |
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