دورية أكاديمية
أعرض في EDS

Novel source of human hematopoietic stem cells from peritoneal dialysis effluents

التفاصيل البيبلوغرافية
العنوان: Novel source of human hematopoietic stem cells from peritoneal dialysis effluents
المؤلفون: Jinhui Shen, Junke Zheng, Ramesh Saxena, ChengCheng Zhang, Liping Tang
المصدر: Stem Cell Research, Vol 15, Iss 2, Pp 299-304 (2015)
بيانات النشر: Elsevier, 2015.
سنة النشر: 2015
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: Peritoneal dialysis, Hematopoietic stem cells, Biology (General), QH301-705.5
الوصف: Hematopoietic stem cells (HSCs) hold great promise for the treatment of various diseases and blood disorders. However, limited availability of these cells has hampered their applications in clinical and biological research. Here we have identified a new source of autologous human HSCs in peritoneal dialysis (PD) effluents from patients with end stage renal diseases (ESRDs). Cells isolated from PD effluents contain a Lin−/CD34+/CD38−/CD90+ sub-population and can repopulate NOD/SCID/gamma−/− mice in serial transplantation. Differing from cord blood HSCs, PD-derived HSCs have high tendencies to repopulate peritoneal cavity and spleen with myeloid cells and B lymphocytes. Repopulating HSCs also reside in peritoneal cavities in mice. The isolation of HSCs from peritoneal cavities provides a novel and promising source of autologous and functional HSCs for stem cell research and possible clinical use.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1873-5061
1876-7753
Relation: http://www.sciencedirect.com/science/article/pii/S1873506115000987; https://doaj.org/toc/1873-5061; https://doaj.org/toc/1876-7753
DOI: 10.1016/j.scr.2015.07.003
URL الوصول: https://doaj.org/article/c54f0dcf3239425b82de4bbe7e64a65a
رقم الأكسشن: edsdoj.54f0dcf3239425b82de4bbe7e64a65a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:18735061
18767753
DOI:10.1016/j.scr.2015.07.003