دورية أكاديمية
أعرض في EDS

In vivo generated human CAR T cells eradicate tumor cells

التفاصيل البيبلوغرافية
العنوان: In vivo generated human CAR T cells eradicate tumor cells
المؤلفون: Shiwani Agarwal, Tatjana Weidner, Frederic B. Thalheimer, Christian J. Buchholz
المصدر: OncoImmunology, Vol 8, Iss 12 (2019)
بيانات النشر: Taylor & Francis Group, 2019.
سنة النشر: 2019
المجموعة: LCC:Immunologic diseases. Allergy
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
مصطلحات موضوعية: cell therapy, car t cells, in vivo gene delivery, receptor targeting, t-cell targeting, Immunologic diseases. Allergy, RC581-607, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
الوصف: Chimeric antigen receptor (CAR) T cells are in prime focus of current research in cancer immunotherapy. Facilitating CAR T cell generation is among the top goals. We have recently demonstrated direct in vivo generation of human CD19-CAR T cells by targeting CD8+ cells using lentiviral vectors (LVs). The anti-tumor potency of in vivo generated CAR T cells was assessed in human PBMC-transplanted NSG mice carrying i.v. injected CD19+ Nalm-6 tumor cells. A single injection of CD8-targeted LV delivering CD19-CAR was sufficient to completely eliminate the tumor cells from bone marrow and spleen, whereas control animals contained high levels of CD19+ cells. Tumor elimination was due to in vivo generated CAR+ cells. Notably, these were not only composed of T lymphocytes but also included CAR+ natural killer cells (NK and NKT). This is the first demonstration of tumor elimination by in vivo generated human CAR T cells.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2162-402X
2162402X
Relation: https://doaj.org/toc/2162-402X
DOI: 10.1080/2162402X.2019.1671761
URL الوصول: https://doaj.org/article/a54ffa6b658d4c4997a6875352cc2e76
رقم الأكسشن: edsdoj.54ffa6b658d4c4997a6875352cc2e76
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:2162402X
DOI:10.1080/2162402X.2019.1671761