Lalit Verma ,1 Mithun Thulasidas ,1 Avnindra Gupta 1 1 Centre for Sight, Delhi 110029, IndiaCorrespondence: Lalit Verma; Mithun ThulasidasCentre for Sight, B-5/24, Safdarjung Enclave, Delhi 110029, IndiaEmail lalitverma@yahoo.com; mithun.thulasidas@gmail.comPurpose: To report a case series of four ocular toxoplasmosis patients who received intravitreal clindamycin as first-line treatment.Materials and Methods: Retrospective interventional case series.Results: Four (two females and two males) patients were diagnosed with active primary toxoplasmic retinochoroiditis based on their clinical presentation. All patients received intravitreal clindamycin 1mg/0.1mL as first-line therapy (two injections with 1-week interval). Oral corticosteroid 1mg/kg/day was also given in a tapering fashion over 4– 6 weeks. A remarkable response was seen in all cases with improved visual acuity, sharpening of the lesion borders, and resolution of inflammation within 4– 6 weeks. No recurrence or reactivation was noted until 2 years follow-up.Conclusion: Intravitreal clindamycin, combined with oral corticosteroids, can be considered an effective and safe first-line therapy for active toxoplasmic retinochoroiditis. It provides the patient a more convenience, safer systemic side effect profile, increased availability, and fewer follow-up visits and hematologic investigations.Keywords: toxoplasmosis, toxoplasmic retinochoroiditis, intravitreal clindamycin, uveitis, vitritis
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