دورية أكاديمية
Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media
| العنوان: | Proteomic Study Identifies Glycolytic and Inflammation Pathways Involved in Recurrent Otitis Media |
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| المؤلفون: | Blendi Ura, Fulvio Celsi, Luisa Zupin, Giorgio Arrigoni, Ilaria Battisti, Bartolomea Gaita, Domenico Leonardo Grasso, Eva Orzan, Raffaella Sagredini, Egidio Barbi, Sergio Crovella |
| المصدر: | International Journal of Molecular Sciences, Vol 21, Iss 23, p 9291 (2020) |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | recurrent otitis, adenotonsillar hypertrophy, 2-DE, proteomics, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | Recurrent acute otitis media (RAOM) in children is clinically defined as the occurrence of at least three episodes of acute otitis media over a course of 6 months. A further common pathological condition of interest in the context of pediatric otolaryngology is adenotonsillar hypertrophy (ATH), a common cause of obstructive sleep apnea syndrome. Aimed at unraveling the differential modulation of proteins in the two pathologies and at understanding the possible pathways involved in their onset, we analyzed the proteomic profile of the adenoids from 14 RAOM and ATH patients by using two-dimensional gel electrophoresis (2-DE) and mass spectrometry (MS). The 2-DE coupled with MS allowed us to identify 23 spots with significant (p-value < 0.05) changes in protein amount, recognizing proteins involved in neutrophil degranulation and glycolysis pathways. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/21/23/9291; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms21239291 |
| URL الوصول: | https://doaj.org/article/5507c00d71504c13a4d490528eef733f |
| رقم الأكسشن: | edsdoj.5507c00d71504c13a4d490528eef733f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms21239291 |