دورية أكاديمية
Effectiveness of a fortified drink in improving B vitamin biomarkers in older adults: a controlled intervention trial
| العنوان: | Effectiveness of a fortified drink in improving B vitamin biomarkers in older adults: a controlled intervention trial |
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| المؤلفون: | Maria Heffernan, Leanne C. Doherty, Roberta Hack Mendes, Michelle Clarke, Stephanie Hodge, Michelle Clements, Liadhan McAnena, Mari Rivelsrud, Mary Ward, J. J. Strain, Helene McNulty, Lorraine Brennan |
| المصدر: | Nutrition & Metabolism, Vol 18, Iss 1, Pp 1-11 (2021) |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Nutrition. Foods and food supply LCC:Nutritional diseases. Deficiency diseases |
| مصطلحات موضوعية: | Folate, Folic acid, Vitamin B12, Vitamin B6, Riboflavin, Fortified drinks, Nutrition. Foods and food supply, TX341-641, Nutritional diseases. Deficiency diseases, RC620-627 |
| الوصف: | Abstract Background Older adults are reported to have sub-optimal B vitamin status; targeted food-based solutions may help to address this. The objectives of the OptiAge food intervention study were to develop and investigate the effectiveness of a B vitamin-fortified drink in improving B vitamin biomarkers in older Irish adults with a primary outcome of change in the B vitamin biomarker status. Methods A double-blinded randomised controlled trial was performed in parallel at University College Dublin and Ulster University. Participants aged > 50 years were recruited following screening for exclusion criteria (i.e. taking medications known to interfere with B vitamin metabolism, supplements containing B vitamins, consuming > 4 portions of B vitamin-fortified foods per week or diagnosed with gastrointestinal, liver or pulmonary disease). Recruited participants meeting the inclusion criteria were randomised (by sex and study centre) to receive daily for 16 weeks either B vitamin-fortified or placebo drinks as developed by Smartfish, Norway. Each B vitamin-fortified drink (200 ml) contained 200 µg folic acid, 10 µg vitamin B12, 10 mg vitamin B6 and 5 mg riboflavin, while the placebo was an identical, isocaloric formulation without added B vitamins. Fasting blood samples were collected pre- and post-intervention which were used to measure the primary outcome of change in B vitamin biomarker levels. Results A total of 95 participants were randomised, of which 81 commenced the trial. Of these, 70 completed (37 in the active and 33 in the placebo groups). Intention to treat (ITT) analysis of the B vitamins demonstrated a significant improvement in all B vitamin biomarkers in the active compared to placebo groups: p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1743-7075 |
| Relation: | https://doaj.org/toc/1743-7075 |
| DOI: | 10.1186/s12986-021-00630-8 |
| URL الوصول: | https://doaj.org/article/c551f44a4de340d2bd585f2915a52784 |
| رقم الأكسشن: | edsdoj.551f44a4de340d2bd585f2915a52784 |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 17437075 |
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| DOI: | 10.1186/s12986-021-00630-8 |