Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters

التفاصيل البيبلوغرافية
العنوان:	Regulation of CAR T cell-mediated cytokine release syndrome-like toxicity using low molecular weight adapters
المؤلفون:	Yong Gu Lee, Haiyan Chu, Yingjuan Lu, Christopher P. Leamon, Madduri Srinivasarao, Karson S. Putt, Philip S. Low
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Chimeric antigen receptor (CAR) T cell anti-cancer therapies might result in toxic side effects. Here the authors present a strategy based on the modulation of CAR T cells via administration of a bispecific adapter that target them to cancer cells, resulting in diminished CAR-T cells toxicity and enhanced solid tumor eradication.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-10565-7
URL الوصول:	https://doaj.org/article/553694276e0c432681cac75ecb3328c9
رقم الأكسشن:	edsdoj.553694276e0c432681cac75ecb3328c9
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-10565-7