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Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria

التفاصيل البيبلوغرافية
العنوان: Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
المؤلفون: Huiqin Zhong, Huiyong Yin
المصدر: Redox Biology, Vol 4, Iss C, Pp 193-199 (2015)
بيانات النشر: Elsevier, 2015.
سنة النشر: 2015
المجموعة: LCC:Medicine (General)
LCC:Biology (General)
مصطلحات موضوعية: Lipid peroxidation, 4-HNE, Mitochondria, Cancer, Free radicals, Cardiolipin, Medicine (General), R5-920, Biology (General), QH301-705.5
الوصف: Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2213-2317
Relation: http://www.sciencedirect.com/science/article/pii/S2213231714001359; https://doaj.org/toc/2213-2317
DOI: 10.1016/j.redox.2014.12.011
URL الوصول: https://doaj.org/article/5539cb426ed64edc8306b9c5c2de0e83
رقم الأكسشن: edsdoj.5539cb426ed64edc8306b9c5c2de0e83
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:22132317
DOI:10.1016/j.redox.2014.12.011