دورية أكاديمية
Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria
العنوان: | Role of lipid peroxidation derived 4-hydroxynonenal (4-HNE) in cancer: Focusing on mitochondria |
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المؤلفون: | Huiqin Zhong, Huiyong Yin |
المصدر: | Redox Biology, Vol 4, Iss C, Pp 193-199 (2015) |
بيانات النشر: | Elsevier, 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
مصطلحات موضوعية: | Lipid peroxidation, 4-HNE, Mitochondria, Cancer, Free radicals, Cardiolipin, Medicine (General), R5-920, Biology (General), QH301-705.5 |
الوصف: | Oxidative stress-induced lipid peroxidation has been associated with human physiology and diseases including cancer. Overwhelming data suggest that reactive lipid mediators generated from this process, such as 4-hydroxynonenal (4-HNE), are biomarkers for oxidative stress and important players for mediating a number of signaling pathways. The biological effects of 4-HNE are primarily due to covalent modification of important biomolecules including proteins, DNA, and phospholipids containing amino group. In this review, we summarize recent progress on the role of 4-HNE in pathogenesis of cancer and focus on the involvement of mitochondria: generation of 4-HNE from oxidation of mitochondria-specific phospholipid cardiolipin; covalent modification of mitochondrial proteins, lipids, and DNA; potential therapeutic strategies for targeting mitochondrial ROS generation, lipid peroxidation, and 4-HNE. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2213-2317 |
Relation: | http://www.sciencedirect.com/science/article/pii/S2213231714001359; https://doaj.org/toc/2213-2317 |
DOI: | 10.1016/j.redox.2014.12.011 |
URL الوصول: | https://doaj.org/article/5539cb426ed64edc8306b9c5c2de0e83 |
رقم الأكسشن: | edsdoj.5539cb426ed64edc8306b9c5c2de0e83 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 22132317 |
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DOI: | 10.1016/j.redox.2014.12.011 |