دورية أكاديمية

Viral Hepatitis C New Microelimination Pathways Objective: Psychiatric Communities HCV Free

التفاصيل البيبلوغرافية
العنوان: Viral Hepatitis C New Microelimination Pathways Objective: Psychiatric Communities HCV Free
المؤلفون: Vito Fiore, Andrea De Vito, Agnese Colpani, Valentina Manca, Ivana Maida, Giordano Madeddu, Sergio Babudieri
المصدر: Life, Vol 12, Iss 11, p 1873 (2022)
بيانات النشر: MDPI AG, 2022.
سنة النشر: 2022
المجموعة: LCC:Science
مصطلحات موضوعية: chronic HCV hepatitis, microelimination programs, psychiatric disorders, DAAs, Science
الوصف: Background: People with psychiatric disorders have a high prevalence of HCV. For this reason, tailored interventions should be developed to reach this population. Methods: We performed a retrospective study on patients treated for HCV infection in psychiatric nursing homes, approached with a quick diagnosis, staging and treatment. Results: We included data on 586 people screened for HCV with quick tests. High HCV seroprevalence was found in this population (231; 39.4%). Among people who tested positive, there were high rates of active infection (220; 95.2%). Out of the 220 patients with active infection, 95.9% were male, 85.5% were Italian, median age was 43 (IQR = 35–52) years old. In the majority of cases (162; 73.6%), the risk factor was unknown. The most common genotype was 3a (98; 44.5%), and patients mostly had a low fibrosis, according with FIB-4 value (142; 64.5%). Of them, one (0.45%) categorically refused the treatment, and one (0.45%) had liver cirrhosis and advanced hepatocellular carcinoma. Overall, 218 patients underwent eligibility for DAAs. The most prescribed treatment was glecaprevir/pibrentasvir (GLE/PIB (172; 78.2%)). The others practiced sofosbuvir/velpatasvir (SOF/VEL). All patients reached the end of treatment. One (0.45%) was lost to follow up, and all the others reached the SVR12. Conclusions: The point-of-care testing and pangenotypic DAAs’ availability represent one of the most important steps for a fast diagnostic and therapeutical option. Tailored microelimination pathways for every difficult-to-reach/to-treat populations are needed. This would allow us to move more easily towards HCV elimination.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2075-1729
Relation: https://www.mdpi.com/2075-1729/12/11/1873; https://doaj.org/toc/2075-1729
DOI: 10.3390/life12111873
URL الوصول: https://doaj.org/article/c555fb82bb4d40a7b4424d9001187c70
رقم الأكسشن: edsdoj.555fb82bb4d40a7b4424d9001187c70
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20751729
DOI:10.3390/life12111873