دورية أكاديمية
Clozapine-associated neutropenia following augmentation with sodium valproate
العنوان: | Clozapine-associated neutropenia following augmentation with sodium valproate |
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المؤلفون: | Michelle Iris Jakobsen, H Grønborg, H V Hansen, A Fink-Jensen |
المصدر: | SAGE Open Medical Case Reports, Vol 9 (2021) |
بيانات النشر: | SAGE Publishing, 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Medicine (General) |
مصطلحات موضوعية: | Medicine (General), R5-920 |
الوصف: | Clozapine is gold standard for the management of treatment-resistant schizophrenia. It can offer life-changing symptom reduction where other antipsychotics have failed, and for these patients, treatment with clozapine should be maintained, if in any possible way. However, treatment with clozapine comes with a risk of developing potentially fatal adverse reactions, for example, severe neutropenia or agranulocytosis, in which case, treatment must be discontinued. Here, we present a case of clozapine-related neutropenia that commenced after the addition of sodium valproate. A subsequent re-challenge to clozapine resulted in severe neutropenia and led to the permanent cessation of clozapine treatment. The patient had been tolerating clozapine for more than a year before the addition of sodium valproate. The awareness of an interaction between clozapine and sodium valproate could help reduce the risk of clozapine-induced neutropenia and subsequent clozapine discontinuation. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2050-313X 2050313X |
Relation: | https://doaj.org/toc/2050-313X |
DOI: | 10.1177/2050313X211019791 |
URL الوصول: | https://doaj.org/article/5576afc4b5e34be28c266772670d19d6 |
رقم الأكسشن: | edsdoj.5576afc4b5e34be28c266772670d19d6 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 2050313X |
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DOI: | 10.1177/2050313X211019791 |