دورية أكاديمية
T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance
| العنوان: | T Helper Cells Fate Mapping by Co-stimulatory Molecules and its Functions in Allograft Rejection and Tolerance |
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| المؤلفون: | R Abdoli, N Najafian |
| المصدر: | International Journal of Organ Transplantation Medicine, Vol 5, Iss 3 (2014) |
| بيانات النشر: | Shiraz University of Medical Sciences, 2014. |
| سنة النشر: | 2014 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | T cell receptor, Receptors, Antigen, B-Cell, Major histocompatibility complex, Transplantation, Antigens, differentiation, T-lymphocyte, Transplantation tolerance, T-Lymphocytes, helper-inducer, T-Lymphocytes, regulatory, Medicine |
| الوصف: | T cell differentiation is dictated by a combination of T cell receptor (TCR) interaction with an antigen-bound major histocompatibility complex (MHC), and co-stimulatory molecules signal. The co-stimulatory signal can be positive or negative, and amplifying or diminishing the initial signal. However, the secondary co-stimulatory signal is not obligatory and its necessity is dictated, in part, by the stage of T cell development. In the field of transplantation, directing the T cell differentiation process can lead to therapeutic possibilities that promote allograft tolerance, and hinder unfavorable alloimmune responses. Therefore, understanding the details of T cell differentiation process, including the influence of co-stimulatory signals, is of paramount importance. It is important to note there is functional overlap between co-stimulatory molecules. It has been observed that some co-stimulatory signals have different effects on different T cell subsets. Hence, blockade of a co-stimulatory signal pathway, as part of a therapeutic regimen in transplantation, may have far reaching effects beyond the initial therapeutic intent and inhibit co-stimulatory signals necessary for desirable regulatory responses. In this review, co-stimulatory molecules involved in the differentiation of naïve T cells into T helper 1 (Th1), T helper 2 (Th2), T helper 17 (Th17), inducible regulatory T cells (iTregs), and T helper 9 (Th9) cells and their overlap are discussed. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2008-6482 2008-6490 |
| Relation: | http://www.ijotm.com/ojs/index.php/IJOTM/article/view/204; https://doaj.org/toc/2008-6482; https://doaj.org/toc/2008-6490 |
| URL الوصول: | https://doaj.org/article/557788dd166b448787c6c4aea597bb37 |
| رقم الأكسشن: | edsdoj.557788dd166b448787c6c4aea597bb37 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20086482 20086490 |
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