دورية أكاديمية
The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators
| العنوان: | The Natural Combination Medicine Traumeel (Tr14) Improves Resolution of Inflammation by Promoting the Biosynthesis of Specialized Pro-Resolving Mediators |
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| المؤلفون: | Paul M. Jordan, Emeline van Goethem, Andrea M. Müller, Kathrin Hemmer, Virginie Gavioli, Vincent Baillif, Yvonne Burmeister, Natascha Krömmelbein, Marc Dubourdeau, Bernd Seilheimer, Oliver Werz |
| المصدر: | Pharmaceuticals, Vol 14, Iss 11, p 1123 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Medicine LCC:Pharmacy and materia medica |
| مصطلحات موضوعية: | lipid mediator, specialized pro-resolving mediators, resolution index, inflammation, efferocytosis, peritonitis, Medicine, Pharmacy and materia medica, RS1-441 |
| الوصف: | The resolution of inflammation is an integral part of the acute inflammatory response and eventually leads to the return to homeostasis. It is supported by specialized pro-resolving mediators (SPMs) that act as immunoresolvents via specific G-protein-coupled receptors. In contrast to classical non-steroidal anti-inflammatory drugs (NSAIDs) that suppress the formation of pro-inflammatory lipid mediators such as prostaglandins, novel pharmacotherapeutic concepts propose to foster the biosynthesis of beneficial SPMs. Here, we demonstrate that the natural combination medicine Traumeel (Tr14) improves resolution of inflammation by promoting SPM formation. Tr14 enhanced the biosynthesis of 12-/15-lipoxygenase (LOX) products and of SPMs in zymosan-induced mouse peritonitis as well as in human monocyte-derived macrophages challenged with Staphylococcus aureus. Importantly, in the peritonitis model, Tr14 supported the recruitment of innate leukocytes and the efferocytotic capacity of macrophages, and positively influenced the inflammation resolution index. Taken together, we suggest that based on these properties Tr14 may possess therapeutic potential as an enhancer for the resolution of inflammatory processes. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1424-8247 |
| Relation: | https://www.mdpi.com/1424-8247/14/11/1123; https://doaj.org/toc/1424-8247 |
| DOI: | 10.3390/ph14111123 |
| URL الوصول: | https://doaj.org/article/55f1d332c147488e8241f5eb2dfdd6dc |
| رقم الأكسشن: | edsdoj.55f1d332c147488e8241f5eb2dfdd6dc |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14248247 |
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| DOI: | 10.3390/ph14111123 |