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High-sensitivity C-reactive protein predicts mortality and technique failure in peritoneal dialysis patients.

التفاصيل البيبلوغرافية
العنوان: High-sensitivity C-reactive protein predicts mortality and technique failure in peritoneal dialysis patients.
المؤلفون: Shou-Hsuan Liu, Yi-Jung Li, Hsin-Hsu Wu, Cheng-Chia Lee, Chan-Yu Lin, Cheng-Hao Weng, Yung-Chang Chen, Ming-Yang Chang, Hsiang-Hao Hsu, Ji-Tseng Fang, Cheng-Chieh Hung, Chih-Wei Yang, Ya-Chung Tian
المصدر: PLoS ONE, Vol 9, Iss 3, p e93063 (2014)
بيانات النشر: Public Library of Science (PLoS), 2014.
سنة النشر: 2014
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: INTRODUCTION: An elevated level of serum C-reactive protein (CRP) is widely considered an indicator of an underlying inflammatory disease and a long-term prognostic predictor for dialysis patients. This cross-sectional cohort study was designed to assess the correlation between the level of high-sensitivity CRP (HS-CRP) and the outcome of peritoneal dialysis (PD) patients. METHODS: A total of 402 patients were stratified into 3 tertiles (lower, middle, upper) according to serum HS-CRP level and and followed up from October 2009 to September 2011. During follow-up, cardiovascular events, infection episodes, technique failure, and mortality rate were recorded. RESULTS: During the 24-month follow-up, 119 of 402 patients (29.6%) dropped out from PD, including 28 patients (7.0%) who died, 81 patients (20.1%) who switched to hemodialysis, and 10 patients (2.5%) who underwent kidney transplantation. The results of Kaplan-Meier analysis and log-rank test demonstrated a significant difference in the cumulative patient survival rate across the 3 tertiles (the lowest rate in upper tertile). On multivariate Cox regression analysis, only higher HS-CRP level, older age, the presence of diabetes mellitus (DM), lower serum albumin level, and the occurrence of cardiovascular events during follow-up were identified as independent predictors of mortality. Every 1 mg/L increase in HS-CRP level was independently predictive of a 1.4% increase in mortality. Multivariate Cox regression analysis also showed that higher HS-CRP level, the presence of DM, lower hemoglobin level, lower serum albumin level, higher dialysate/plasma creatinine ratio, and the occurrence of infective episodes and cardiovascular events during follow-up were independent predictors of technique failure. CONCLUSIONS: The present study shows the importance of HS-CRP in the prediction of 2-year mortality and technique survival in PD patients independent of age, diabetes, hypoalbuminemia, and the occurrence of cardiovascular events.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: http://europepmc.org/articles/PMC3965534?pdf=render; https://doaj.org/toc/1932-6203
DOI: 10.1371/journal.pone.0093063
URL الوصول: https://doaj.org/article/566a5e50968047319f0c67f131aa9d95
رقم الأكسشن: edsdoj.566a5e50968047319f0c67f131aa9d95
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203
DOI:10.1371/journal.pone.0093063