دورية أكاديمية
Changes in Faecal Microbiota Profile and Plasma Biomarkers following the Administration of an Antioxidant Oleuropein-Rich Leaf Extract in a Rat Model Mimicking Colorectal Cancer
| العنوان: | Changes in Faecal Microbiota Profile and Plasma Biomarkers following the Administration of an Antioxidant Oleuropein-Rich Leaf Extract in a Rat Model Mimicking Colorectal Cancer |
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| المؤلفون: | Sofia Chioccioli, Gabriele Rocchetti, Jessica Ruzzolini, Silvia Urciuoli, Francesco Vitali, Gianluca Bartolucci, Marco Pallecchi, Giovanna Caderni, Carlotta De Filippo, Chiara Nediani, Luigi Lucini |
| المصدر: | Antioxidants, Vol 13, Iss 6, p 724 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | colorectal cancer, PIRC rats, plasma biomarkers, secoiridoids, untargeted metabolomics, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Oleuropein (OLE), a phenolic compound particularly abundant in the olive leaves, has been reported to have beneficial activities against colorectal cancer (CRC). In vitro studies suggested that these latter could be due to a modulation of the intestinal microbiota. Aiming to evaluate if OLE could affect the intestinal microbiota and the plasma metabolome, an antioxidant oleuropein-rich leaf extract (ORLE) was administered for one week to PIRC rats (F344/NTac-Apcam1137), a genetic model mimicking CRC. ORLE treatment significantly modulated the gut microbiota composition. Plasma metabolomic profiles revealed a significant predictive ability for amino acids, medium-chain fatty acids, and aldehydes. Pathway analysis revealed a significant decrease in phosphatidylcholine accumulation (LogFC = −1.67) in PIRC rats. These results suggest a significant effect of ORLE administration on faecal microbiota profiles and plasma metabolomes, thereby offering new omics-based insights into its protective role in CRC progression. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 13060724 2076-3921 |
| Relation: | https://www.mdpi.com/2076-3921/13/6/724; https://doaj.org/toc/2076-3921 |
| DOI: | 10.3390/antiox13060724 |
| URL الوصول: | https://doaj.org/article/566bce8fae414b149a628bbedca6c780 |
| رقم الأكسشن: | edsdoj.566bce8fae414b149a628bbedca6c780 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 13060724 20763921 |
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| DOI: | 10.3390/antiox13060724 |