دورية أكاديمية
Fibronectin Molecular Status in Plasma of Women with Endometriosis and Fertility Disorders
| العنوان: | Fibronectin Molecular Status in Plasma of Women with Endometriosis and Fertility Disorders |
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| المؤلفون: | Jolanta Lis-Kuberka, Paulina Kubik, Agnieszka Chrobak, Jarosław Pająk, Anna Chełmońska-Soyta, Magdalena Orczyk-Pawiłowicz |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 21, p 11410 (2021) |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | endometriosis, fertility disorders, molecular status of fibronectin, fibrin, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The diagnosis of endometriosis and fertility disorders is difficult; therefore, it is necessary to look for reliable biomarkers. Analysis of the molecular status of fibronectin as a key player in repair and wound healing processes, as well as in coagulation and fibrinolysis pathways, is justified. ELISA and SDS-agarose immunoblotting were applied to determine the fibronectin concentration and presence and occurrence of soluble FN-fibrin complexes in the blood plasma of women with endometriosis (n = 38), fertility disorders (n = 28) and the healthy group (n = 25). The concentration of fibronectin in the blood plasma of women with endometriosis (292.61 ± 96.17 mg/L) and fertility disorders (287.53 ± 122.68 mg/L) was significantly higher than in the normal group (226.55 ± 91.98 mg/L). The presence of FN-fibrin complexes of 750, 1000, 1300, 1600 and 1900 kDa in the plasma of women with endometriosis and fertility disorders was shown. The presence of FN-fibrin complexes with a molecular mass of more than 1300 kDa in women with endometriosis and infertility and the complete absence of these complexes in healthy women may indicate an increased and chronic activation of coagulation mechanisms in these patients. The presence of complexes of high molecular mass may be one of the biomarkers of fertility disorders in women. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/22/21/11410; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms222111410 |
| URL الوصول: | https://doaj.org/article/57333a0be7f04b398f534741996659c4 |
| رقم الأكسشن: | edsdoj.57333a0be7f04b398f534741996659c4 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 14220067 16616596 |
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| DOI: | 10.3390/ijms222111410 |