دورية أكاديمية
Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus
| العنوان: | Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett’s Esophagus |
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| المؤلفون: | Cheima Hicheri, Ahad M. Azimuddin, Alex Kortum, Joseph Bailey, Yubo Tang, Richard A. Schwarz, Daniel Rosen, Shilpa Jain, Nabil M. Mansour, Shawn Groth, Shaleen Vasavada, Ashwin Rao, Adrianna Maliga, Leslie Gallego, Jennifer Carns, Sharmila Anandasabapathy, Rebecca Richards-Kortum |
| المصدر: | Bioengineering, Vol 11, Iss 6, p 557 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Technology LCC:Biology (General) |
| مصطلحات موضوعية: | Barrett’s esophagus, narrow-band imaging, digital chromoendoscopy, capsule endoscopy, low-resource settings, cancer detection, Technology, Biology (General), QH301-705.5 |
| الوصف: | Esophageal carcinoma is the sixth-leading cause of cancer death worldwide. A precursor to esophageal adenocarcinoma (EAC) is Barrett’s Esophagus (BE). Early-stage diagnosis and treatment of esophageal neoplasia (Barrett’s with high-grade dysplasia/intramucosal cancer) increase the five-year survival rate from 10% to 98%. BE is a global challenge; however, current endoscopes for early BE detection are costly and require extensive infrastructure for patient examination and sedation. We describe the design and evaluation of the first prototype of ScanCap, a high-resolution optical endoscopy system with a reusable, low-cost tethered capsule, designed to provide high-definition, blue-green illumination imaging for the early detection of BE in unsedated patients. The tethered capsule (12.8 mm diameter, 35.5 mm length) contains a color camera and rotating mirror and is designed to be swallowed; images are collected as the capsule is retracted manually via the tether. The tether provides electrical power and illumination at wavelengths of 415 nm and 565 nm and transmits data from the camera to a tablet. The ScanCap prototype capsule was used to image the oral mucosa in normal volunteers and ex vivo esophageal resections; images were compared to those obtained using an Olympus CV-180 endoscope. Images of superficial capillaries in intact oral mucosa were clearly visible in ScanCap images. Diagnostically relevant features of BE, including irregular Z-lines, distorted mucosa, and dilated vasculature, were clearly visible in ScanCap images of ex vivo esophageal specimens. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 11060557 2306-5354 |
| Relation: | https://www.mdpi.com/2306-5354/11/6/557; https://doaj.org/toc/2306-5354 |
| DOI: | 10.3390/bioengineering11060557 |
| URL الوصول: | https://doaj.org/article/57837e1297a9400fb5949c369e99e7c2 |
| رقم الأكسشن: | edsdoj.57837e1297a9400fb5949c369e99e7c2 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 11060557 23065354 |
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| DOI: | 10.3390/bioengineering11060557 |