eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma

التفاصيل البيبلوغرافية
العنوان:	eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma
المؤلفون:	Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa Yao, Faith Gorton, Junwei Shi, Craig J. Thomas, Lauren E. Brown, John A. Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
المصدر:	Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
بيانات النشر:	Nature Portfolio, 2019.
سنة النشر:	2019
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Metabolic reprogramming is a hallmark of pancreatic ductal adenocarcinoma (PDA). Here, the authors show that in PDA cells redox and central carbon metabolism are driven by an eIF4F dependent translation program, and combined targeting of eIF4A and glutaminase can impact PDA proliferation.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-019-13086-5
URL الوصول:	https://doaj.org/article/5805d19b9df44bceaf4b4ac6e534ad64
رقم الأكسشن:	edsdoj.5805d19b9df44bceaf4b4ac6e534ad64
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-019-13086-5