دورية أكاديمية
Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation
| العنوان: | Microbiota Normalization Reveals that Canonical Caspase-1 Activation Exacerbates Chemically Induced Intestinal Inflammation |
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| المؤلفون: | Adrian J. Błażejewski, Sophie Thiemann, Alexander Schenk, Marina C. Pils, Eric J.C. Gálvez, Urmi Roy, Ulrike Heise, Marcel R. de Zoete, Richard A. Flavell, Till Strowig |
| المصدر: | Cell Reports, Vol 19, Iss 11, Pp 2319-2330 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | caspase-1, caspase-11, colitis, inflammasome, microbiota, colon, intestine, DSS, inflammation-induced tumorigenesis, Biology (General), QH301-705.5 |
| الوصف: | Inflammasomes play a central role in regulating intestinal barrier function and immunity during steady state and disease. Because the discoveries of a passenger mutation and a colitogenic microbiota in the widely used caspase-1-deficient mouse strain have cast doubt on previously identified direct functions of caspase-1, we reassessed the role of caspase-1 in the intestine. To this end, we generated Casp1−/− and Casp11−/− mice and rederived them into an enhanced barrier facility to standardize the microbiota. We found that caspase-11 does not influence caspase-1-dependent processing of IL-18 in homeostasis and during DSS colitis. Deficiency of caspase-1, but not caspase-11, ameliorated the severity of DSS colitis independent of microbiota composition. Ablation of caspase-1 in intestinal epithelial cells was sufficient to protect mice against DSS colitis. Moreover, Casp1−/− mice developed fewer inflammation-induced intestinal tumors than control mice. These data show that canonical inflammasome activation controls caspase-1 activity, contributing to exacerbation of chemical-induced colitis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-1247 42517974 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2211124717307155; https://doaj.org/toc/2211-1247 |
| DOI: | 10.1016/j.celrep.2017.05.058 |
| URL الوصول: | https://doaj.org/article/580ae42517974a368b8e6a328b0ee750 |
| رقم الأكسشن: | edsdoj.580ae42517974a368b8e6a328b0ee750 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 22111247 42517974 |
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| DOI: | 10.1016/j.celrep.2017.05.058 |