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Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes

التفاصيل البيبلوغرافية
العنوان: Role of IgG against N-protein of SARS-CoV2 in COVID19 clinical outcomes
المؤلفون: Mayank Batra, Runxia Tian, Chongxu Zhang, Emile Clarence, Camila Sofia Sacher, Justin Nestor Miranda, Justin Rafa O. De La Fuente, Megan Mathew, Desmond Green, Sayari Patel, Maria Virginia Perez Bastidas, Sara Haddadi, Mukunthan Murthi, Miguel Santiago Gonzalez, Shweta Kambali, Kayo H. M. Santos, Huda Asif, Farzaneh Modarresi, Mohammad Faghihi, Mehdi Mirsaeidi
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
بيانات النشر: Nature Portfolio, 2021.
سنة النشر: 2021
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract The Nucleocapsid Protein (N Protein) of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV2) is located in the viral core. Immunoglobulin G (IgG) targeting N protein is detectable in the serum of infected patients. The effect of high titers of IgG against N-protein on clinical outcomes of SARS-CoV2 disease has not been described. We studied 400 RT-PCR confirmed SARS-CoV2 patients to determine independent factors associated with poor outcomes, including Medical Intensive Care Unit (MICU) admission, prolonged MICU stay and hospital admissions, and in-hospital mortality. We also measured serum IgG against the N protein and correlated its concentrations with clinical outcomes. We found that several factors, including Charlson comorbidity Index (CCI), high levels of IL6, and presentation with dyspnea were associated with poor clinical outcomes. It was shown that higher CCI and higher IL6 levels were independently associated with in-hospital mortality. Anti-N protein IgG was detected in the serum of 55 (55%) patients at the time of admission. A high concentration of antibodies, defined as signal to cut off ratio (S/Co) > 1.5 (75 percentile of all measurements), was found in 25 (25%) patients. The multivariable logistic regression models showed that between being an African American, higher CCI, lymphocyte counts, and S/Co ratio > 1.5, only S/Co ratio were independently associated with MICU admission and longer length of stay in hospital. This study recommends that titers of IgG targeting N-protein of SARS-CoV2 at admission is a prognostic factor for the clinical course of disease and should be measured in all patients with SARS-CoV2 infection.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
Relation: https://doaj.org/toc/2045-2322
DOI: 10.1038/s41598-021-83108-0
URL الوصول: https://doaj.org/article/581137ccf5854a13a0c73fa00760ace2
رقم الأكسشن: edsdoj.581137ccf5854a13a0c73fa00760ace2
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-021-83108-0