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The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice

التفاصيل البيبلوغرافية
العنوان: The Rostromedial Tegmental Nucleus: Anatomical Studies and Roles in Sleep and Substance Addictions in Rats and Mice
المؤلفون: Zhao YN, Yan YD, Wang CY, Qu WM, Jhou TC, Huang ZL, Yang SR
المصدر: Nature and Science of Sleep, Vol Volume 12, Pp 1215-1223 (2020)
بيانات النشر: Dove Medical Press, 2020.
سنة النشر: 2020
المجموعة: LCC:Psychiatry
LCC:Neurophysiology and neuropsychology
مصطلحات موضوعية: rostromedial tegmental nucleus, anatomical location, sleep–wake behavior, projections, addiction, Psychiatry, RC435-571, Neurophysiology and neuropsychology, QP351-495
الوصف: Ya-Nan Zhao,1,* Yu-Dong Yan,1,* Chen-Yao Wang,1 Wei-Min Qu,1 Thomas C Jhou,2 Zhi-Li Huang,1 Su-Rong Yang1 1Department of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of China; 2Department of Neuroscience, Medical University of South Carolina, Charleston, SC, USA*These authors contributed equally to this workCorrespondence: Su-Rong Yang; Zhi-Li HuangDepartment of Pharmacology, School of Basic Medical Sciences, Fudan University, Shanghai, People’s Republic of ChinaTel/Fax +86-21-54237228; +86-21-54237103Email sryang@shmu.edu.cn; huangzl@fudan.edu.cnAbstract: The rostromedial tegmental nucleus (RMTg), a brake of the dopamine system, is specifically activated by aversive stimuli, such as foot shock. It is principally composed of gamma-aminobutyric acid neurons. However, there is no exact location of the RMTg on the brain stereotaxic atlas. The RMTg can be defined by c-Fos staining elicited by psychostimulants, the position of retrograde-labeled neurons stained by injections into the ventral tegmental area (VTA), the terminal field formed by axons from the lateral habenula, and some molecular markers identified as specifically expressed in the RMTg such as FoxP1. The RMTg receives a broad range of inputs and produces diverse outputs, which indicates that the RMTg has multiple functions. First, the RMTg plays an essential role for non-rapid eye movement sleep. Additionally, the RMTg serves a vital role in response to addiction. Opiates increase the firing rates of dopaminergic neurons in the VTA by acting on μ-opioid receptors on RMTg neurons and their terminals inside the VTA. In this review, we summarize the recent research advances on the anatomical location of the RMTg in rats and mice, its projections, and its regulation of sleep–wake behavior and addiction.Keywords: rostromedial tegmental nucleus, anatomical location, projections, sleep–wake behavior, addiction
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1179-1608
Relation: https://www.dovepress.com/the-rostromedial-tegmental-nucleus-anatomical-studies-and-roles-in-sle-peer-reviewed-article-NSS; https://doaj.org/toc/1179-1608
URL الوصول: https://doaj.org/article/5815803c48614b9981c2b066dc5d9d3a
رقم الأكسشن: edsdoj.5815803c48614b9981c2b066dc5d9d3a
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:11791608