دورية أكاديمية
The use of febuxostat in comorbid patients with gout in real clinical practice: own data
| العنوان: | The use of febuxostat in comorbid patients with gout in real clinical practice: own data |
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| المؤلفون: | E. V. Zonova, D. N. Orlov, A. S. Kabargina |
| المصدر: | Современная ревматология, Vol 16, Iss 3, Pp 75-80 (2022) |
| بيانات النشر: | IMA-PRESS LLC, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | подагра, коморбидность, фебуксостат, гиперурикемия, эффективность, безопасность, Medicine |
| الوصف: | Objective: to evaluate the efficacy and safety of febuxostat (Azuriks®) in the treatment of patients with gout and concomitant diseases.Patients and methods. An observational, open-label, single-centre study of the results of febuxostat use in 85 gout patients with insufficient prior allopurinol efficacy or its intolerance. The median age of patients was 56.2 [49; 59] years, among them 83.5% were men. All patients had comorbid diseases, mainly cardiovascular pathology (76.5%) and chronic kidney disease (60%). The achievement of target values of uric acid (UA) during 4 months of urate-lowering therapy and its safety were assessed.Results and discussion. After 4 months of therapy with febuxostat, 25% of patients reached the target values of UA. Exacerbations at an early stage of the use of urate-lowering therapy were rare and were characterized by a lesser severity of the articular syndrome. Normalization of purine metabolism was accompanied by a decrease in the laboratory activity index (CRP level) to values corresponding to the interictal period of gout. Febuxostat was well tolerated.Conclusion. According to the data obtained, in patients with gout and concomitant diseases, febuxostat allows reaching target UA values in a short time without dose titration, while a high safety profile is noted. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | Russian |
| تدمد: | 1996-7012 2310-158X |
| Relation: | https://mrj.ima-press.net/mrj/article/view/1301; https://doaj.org/toc/1996-7012; https://doaj.org/toc/2310-158X |
| DOI: | 10.14412/1996-7012-2022-3-75-80 |
| URL الوصول: | https://doaj.org/article/c581cb3754534bfa97910db980288a92 |
| رقم الأكسشن: | edsdoj.581cb3754534bfa97910db980288a92 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 19967012 2310158X |
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| DOI: | 10.14412/1996-7012-2022-3-75-80 |