دورية أكاديمية
Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model
| العنوان: | Oxidative Stress and Mitochondrial Complex I Dysfunction Correlate with Neurodegeneration in an α-Synucleinopathy Animal Model |
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| المؤلفون: | Adriana Morales-Martínez, Paola A. Martínez-Gómez, Daniel Martinez-Fong, Marcos M. Villegas-Rojas, Francisca Pérez-Severiano, Miguel A. Del Toro-Colín, Karen M. Delgado-Minjares, Víctor Manuel Blanco-Alvarez, Bertha Alicia Leon-Chavez, Omar Emiliano Aparicio-Trejo, Mauricio T. Baéz-Cortés, Maria-del-Carmen Cardenas-Aguayo, José Luna-Muñoz, Mar Pacheco-Herrero, Quetzalli D. Angeles-López, Irma A. Martínez-Dávila, Citlaltepetl Salinas-Lara, José Pablo Romero-López, Carlos Sánchez-Garibay, Adolfo R. Méndez-Cruz, Luis O. Soto-Rojas |
| المصدر: | International Journal of Molecular Sciences, Vol 23, Iss 19, p 11394 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Biology (General) LCC:Chemistry |
| مصطلحات موضوعية: | Parkinson’s disease, α-synucleinopathy, mitochondrial dysfunction, BSSG, oxidative stress, nitrosative stress, Biology (General), QH301-705.5, Chemistry, QD1-999 |
| الوصف: | The α-synucleinopathies constitute a subset of neurodegenerative disorders, of which Parkinson’s disease (PD) is the most common worldwide, characterized by the accumulation of misfolded α-synuclein in the cytoplasm of neurons, which spreads in a prion-like manner to anatomically interconnected brain areas. However, it is not clear how α-synucleinopathy triggers neurodegeneration. We recently developed a rat model through a single intranigral administration of the neurotoxic β-sitosterol β-D-glucoside (BSSG), which produces α-synucleinopathy. In this model, we aimed to evaluate the temporal pattern of levels in oxidative and nitrosative stress and mitochondrial complex I (CI) dysfunction and how these biochemical parameters are associated with neurodegeneration in different brain areas with α-synucleinopathy (Substantia nigra pars compacta, the striatum, in the hippocampus and the olfactory bulb, where α-syn aggregation spreads). Interestingly, an increase in oxidative stress and mitochondrial CI dysfunction accompanied neurodegeneration in those brain regions. Furthermore, in silico analysis suggests a high-affinity binding site for BSSG with peroxisome proliferator-activated receptors (PPAR) alpha (PPAR-α) and gamma (PPAR-γ). These findings will contribute to elucidating the pathophysiological mechanisms associated with α-synucleinopathies and lead to the identification of new early biomarkers and therapeutic targets. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 23191139 1422-0067 1661-6596 |
| Relation: | https://www.mdpi.com/1422-0067/23/19/11394; https://doaj.org/toc/1661-6596; https://doaj.org/toc/1422-0067 |
| DOI: | 10.3390/ijms231911394 |
| URL الوصول: | https://doaj.org/article/582d89ba51504c4487ec0c54b6e9e357 |
| رقم الأكسشن: | edsdoj.582d89ba51504c4487ec0c54b6e9e357 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23191139 14220067 16616596 |
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| DOI: | 10.3390/ijms231911394 |