دورية أكاديمية
Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject
| العنوان: | Evaluation of L-fucose and Sialic Acid Levels in Patients With Colorectal Cancer and Control Subject |
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| المؤلفون: | Roya Abbasinatajomrani, Durdi Qujeq, Vahid Hosseini, Reza Hajihosseini |
| المصدر: | Research in Molecular Medicine, Vol 8, Iss 3, Pp 137-142 (2020) |
| بيانات النشر: | Mazandaran University of Medical Sciences and Health Services, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine (General) |
| مصطلحات موضوعية: | colorectal cancer, glycosylation, serum markers, Medicine (General), R5-920 |
| الوصف: | Background: Currently, glycans, which are known as functional molecules in the biological system, are being under study as potential cancer markers. This study aimed to determine the level of serum L-fucose and sialic acid as the biomarkers in patients with colorectal cancer (CRC). Materials and Methods: The patients with CRC (n=40, 20 men and 20 women) participated in the present study. The spectrophotometric method was used to measure the levels of L-fucose and sialic acid in the serum of the patients. SPSS (version 21) was used to analyze the obtained data. The results were expressed as mean ± SD. Results: The mean ± SD L-fucose level in patients with CRC was 27.46 ± 4.8 ng/mL, which was more than this level in the healthy control group (18.64±3.1 ng/mL). Also, the mean ± SD serum concentration of sialic acid in patients with CRC was 2.1 ± 0.41 ng/mL, which was more than the mean ± SD sialic acid level of 1.23±0.21 ng/mL in the healthy controls. Conclusion: Serum concentration of L-fucose and sialic acid increased significantly (P < 0.05) in patients with CRC compared with the healthy controls. We believe that determining serum L-fucose and sialic acid levels could be useful for the detection of CRC patients in the early stage. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2322-1348 2322-133X |
| Relation: | http://rmm.mazums.ac.ir/article-1-377-en.html; https://doaj.org/toc/2322-1348; https://doaj.org/toc/2322-133X |
| URL الوصول: | https://doaj.org/article/ee58557aac864b78a527146463fc001e |
| رقم الأكسشن: | edsdoj.58557aac864b78a527146463fc001e |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 23221348 2322133X |
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