دورية أكاديمية
Prognostic Analysis of Patients with Ebola Virus Disease.
العنوان: | Prognostic Analysis of Patients with Ebola Virus Disease. |
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المؤلفون: | Xin Zhang, Yihui Rong, Lijian Sun, Liming Liu, Haibin Su, Jian Zhang, Guangju Teng, Ning Du, Haoyang Chen, Yuan Fang, Wei Zhan, Alex B J Kanu, Sheku M Koroma, Bo Jin, Zhe Xu, Haihan Song |
المصدر: | PLoS Neglected Tropical Diseases, Vol 9, Iss 9, p e0004113 (2015) |
بيانات النشر: | Public Library of Science (PLoS), 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Arctic medicine. Tropical medicine LCC:Public aspects of medicine |
مصطلحات موضوعية: | Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270 |
الوصف: | BACKGROUND:The Ebola virus causes an acute, serious illness which is often fatal if untreated. However, factors affecting the survival of the disease remain unclear. Here, we investigated the prognostic factors of Ebola virus disease (EVD) through various statistical models. METHODOLOGY/PRINCIPAL FINDINGS:Sixty three laboratory-confirmed EVD patients with relatively complete clinical profiles were included in the study. All the patients were recruited at Jui Government Hospital, Sierra Leone between October 1st, 2014 and January 18th, 2015. We first investigated whether a single clinical presentation would be correlated with the survival of EVD. Log-rank test demonstrated that patients with viral load higher than 10(6) copies/ml presented significantly shorter survival time than those whose viral load were lower than 10(6) copies/ml (P = 0.005). Also, using Pearson chi-square test, we identified that chest pain, coma, and viral load (>10(6) copies/ml) were significantly associated with poor survival of EVD patients. Furthermore, we evaluated the effect of multiple variables on the survival of EVD by Cox proportional hazards model. Interestingly, results revealed that patient's age, symptom of confusion, and viral load were the significantly associated with the survival of EVD cases (P = 0.017, P = 0.002, and P = 0.027, respectively). CONCLUSIONS/SIGNIFICANCE:These results suggest that age, chest pain, coma, confusion and viral load are associated with the prognosis of EVD, in which viral load could be one of the most important factors for the survival of the disease. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1935-2727 1935-2735 |
Relation: | http://europepmc.org/articles/PMC4580459?pdf=render; https://doaj.org/toc/1935-2727; https://doaj.org/toc/1935-2735 |
DOI: | 10.1371/journal.pntd.0004113 |
URL الوصول: | https://doaj.org/article/5897f6a9bf2a4263b4496f748adb9162 |
رقم الأكسشن: | edsdoj.5897f6a9bf2a4263b4496f748adb9162 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 19352727 19352735 |
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DOI: | 10.1371/journal.pntd.0004113 |