دورية أكاديمية
Transcriptomics and metabolomics of blood, urine and ovarian follicular fluid of yak at induced estrus stage
| العنوان: | Transcriptomics and metabolomics of blood, urine and ovarian follicular fluid of yak at induced estrus stage |
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| المؤلفون: | Huangqing Zhao, Yongzhen Huang, Shi Shu, Guowen Wang, Changqi Fu, Rong Huang, Jun Zhang, Huawei Su, Yang He, Chuzhao Lei, Lei Du, Jiahao Zhao, Wei Peng |
| المصدر: | BMC Genomics, Vol 25, Iss 1, Pp 1-19 (2024) |
| بيانات النشر: | BMC, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biotechnology LCC:Genetics |
| مصطلحات موضوعية: | Estrus, Yak, Metabolome, Transcriptome, Biotechnology, TP248.13-248.65, Genetics, QH426-470 |
| الوصف: | Abstract To gain a deeper understanding of the metabolic differences within and outside the body, as well as changes in transcription levels following estrus in yaks, we conducted transcriptome and metabolome analyses on female yaks in both estrus and non-estrus states. The metabolome analysis identified 114, 13, and 91 distinct metabolites in urine, blood, and follicular fluid, respectively. The Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis highlighted an enrichment of pathways related to amino acid and lipid metabolism across all three body fluids. Our transcriptome analysis revealed 122 differentially expressed genes within microRNA (miRNA) and 640 within long non-coding RNA (lncRNA). Functional enrichment analysis of lncRNA and miRNA indicated their involvement in cell signaling, disease resistance, and immunity pathways. We constructed a regulatory network composed of 10 lncRNAs, 4 miRNAs, and 30 mRNAs, based on the targeted regulation relationships of the differentially expressed genes. In conclusion, the accumulation of metabolites such as amino acids, steroids, and organic acids, along with the expression changes of key genes like miR-129 during yak estrus, provide initial insights into the estrus mechanism in yaks. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2164 |
| Relation: | https://doaj.org/toc/1471-2164 |
| DOI: | 10.1186/s12864-024-10079-7 |
| URL الوصول: | https://doaj.org/article/58cc6ce765e74f749a826a7497abbdad |
| رقم الأكسشن: | edsdoj.58cc6ce765e74f749a826a7497abbdad |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 14712164 |
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| DOI: | 10.1186/s12864-024-10079-7 |