دورية أكاديمية
The added value of SPECT/CT lymphoscintigraphy in the initial assessment of secondary extremity lymphedema patients
| العنوان: | The added value of SPECT/CT lymphoscintigraphy in the initial assessment of secondary extremity lymphedema patients |
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| المؤلفون: | Hai-Jeon Yoon, Kyong-Je Woo, Ji-Young Kim, Seo Young Kang, Byung Seok Moon, Bom Sahn Kim |
| المصدر: | Scientific Reports, Vol 13, Iss 1, Pp 1-10 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract An added value of SPECT/CT over planar lymphoscintigraphy for initial staging in patients with secondary extremity lymphedema was investigated. Furthermore, we developed a hybrid SPECT/CT classification combining dermal backflow (DBF) of SPECT and honeycomb pattern (HP) of CT, correlated it with lymphoscintigraphic staging and clinical severity. Forty-one patients with secondary extremity lymphedema who underwent lymphoscintigraphy with SPECT/CT were included retrospectively. The severity of extremity lymphedema was assessed using CT volumetry. Lymphoscintigraphic findings were evaluated using the Taiwan Lymphoscintigraphy Staging (TLS), and CT-based and SPECT-based quantitative analysis were performed. TLS was performed by planar scintigraphy only and with SPECT/CT, respectively. The SPECT/CT findings were classified into DBF−/HP−, DBF+/HP−, DBF+/HP+, and DBF−/HP+. Based on these findings, patients were categorized into five classes: Class 1 = DBF−HP− entire limb, Class 2 = DBF+/HP− proximal/distal limb without DBF+/HP+ or DBF−/HP+, Class 3 = DBF+/HP+ proximal/distal limb without DBF−/HP+, Class 4 = Mixed DBF+/HP+ and DBF−/HP+ in proximal/distal limb, Class 5 = DBF−/HP+ entire limb. Adding SPECT/CT to planar scintigraphy showed a 15.4% modification rate in lymphoscintigraphic staging. HP volume ratio significantly increased as clinical severity and lymphoscintigraphic staging increased, while DBF volume ratio increased with severity and followed expected patterns according to lymphoscintigraphic staging. Hybrid SPECT/CT lymphoscintigraphic classification showed strong positive correlation with clinical severity and TLS. Our results demonstrated substantial modification of lymphoscintigraphic staging by adding SPECT/CT to a conventional planar scintigraphy. In addition, a hybrid SPECT/CT is expected to provide new indicators reflecting lymphoscintigraphic staging and clinical severity by providing both of functional DBF and anatomical HP information. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-44471-2 |
| URL الوصول: | https://doaj.org/article/e5962089f6e94464a6025195f20852eb |
| رقم الأكسشن: | edsdoj.5962089f6e94464a6025195f20852eb |
| قاعدة البيانات: | Directory of Open Access Journals |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-023-44471-2 |