Objective To investigate the characteristics of exertional rhabdomyolysis (ERB) and the predictive value of creatine kinase (CK), myoglobin/creatine kinase (Mb/CK) ratio and other indicators for ERB patients with acute renal injury (AKI). Methods The clinical data of 154 patients with ERB admitted to the Affiliated Hospital of Qingdao University from January 2013 to September 2022 were retrospectively analyzed. The patients were divided into AKI group (n=35) and non-AKI group (n=119) according to whether AKI was combined. Creatinine, CK and other laboratory indicators were collected. Univariate and multivariate logistic regression models were used to analyze the risk factors for AKI in ERB patients. Receiver operating characteristic (ROC) curve was used to evaluate the predictive value of related indicators, and the correlation between each indicator and serum creatinine was analyzed by Spearman correlation analysis. Results The main clinical manifestations of 154 ERB patients were muscle pain (140 cases), limb weakness (69 cases), and dark brown urine (36 cases). The levels of CK, creatine kinase isoenzyme (CK-MB), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in non-AKI group were significantly higher than those in AKI group (P＜0.05). The levels of creatinine, lactate dehydrogenase (LDH), cystatin C, Mb/CK and creatinine/cystatin C in AKI group were higher than those in non-AKI group, and the differences were statistically significant (P
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