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Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus

التفاصيل البيبلوغرافية
العنوان: Increased intestinal-fatty acid binding protein in obesity-associated type 2 diabetes mellitus
المؤلفون: Dicky L. Tahapary, Atikah I. Fatya, Farid Kurniawan, Cicilia Marcella, Ikhwan Rinaldi, Tri J. E. Tarigan, Dante S. Harbuwono, Em Yunir, Pradana Soewondo, Dyah Purnamasari
المصدر: PLoS ONE, Vol 18, Iss 1 (2023)
بيانات النشر: Public Library of Science (PLoS), 2023.
سنة النشر: 2023
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Background Obesity is a traditional risk factor for type 2 diabetes mellitus (T2DM). However, recent studies reported that metabolically unhealthy obesity (MUO) exerts a higher risk of developing T2DM than metabolically healthy obesity (MHO) because of its higher state of insulin resistance. This may happen due to metabolic endotoxemia through gut dysbiosis and increased intestinal permeability. Our study aimed to know the association of intestinal permeability using intestinal fatty acid-binding protein (I-FABP) with obesity-related T2DM patients in Indonesia. Methods This was a cross-sectional study that recruited 63 participants with obesity defined using body mass index (BMI) classification for the Asia-Pacific population (BMI ≥25 kg/m2). All participants were then grouped into T2DM and non-T2DM based on American Diabetes Association (ADA) diagnostic criteria. The I-FABP levels were measured using the enzyme-linked immunosorbent assay method. Results The I-FABP level of T2DM group was higher compared to non-T2DM group, namely 2.82 (1.23) ng/mL vs. 1.78 (0.81) ng/mL (pConclusions This study underscores the association of intestinal permeability with T2DM in people with obesity and supports the evidence of the potential role of intestinal permeability in the pathogenesis of obesity-related T2DM.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1932-6203
Relation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9879407/?tool=EBI; https://doaj.org/toc/1932-6203
URL الوصول: https://doaj.org/article/599b10bce84d48dc947a880ea664f99b
رقم الأكسشن: edsdoj.599b10bce84d48dc947a880ea664f99b
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:19326203