دورية أكاديمية
Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy
| العنوان: | Pharmacodynamics and pharmacokinetics of PLGA-based doxorubicin-loaded implants for tumor therapy |
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| المؤلفون: | Peng He, Shenglin Xu, Zehao Guo, Peng Yuan, Yulei Liu, Yu Chen, Tiantian Zhang, Yukang Que, Yong Hu |
| المصدر: | Drug Delivery, Vol 29, Iss 1, Pp 478-488 (2022) |
| بيانات النشر: | Taylor & Francis Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | doxorubicin, sustained release, intratumoral chemotherapy, plga, implants, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | The traditional systemic chemotherapy through intravenous infusion of doxorubicin (DOX) has many side effects. The aim of this study was to develop a PLGA-based DOX-loaded implant and to evaluate the efficacy and drug metabolism distribution of the implant in intratumoral chemotherapy for osteosarcoma (OS). In this study, implants containing DOX, poly(d,l-lactide-co-glycolide), and polyethylene glycol 4000 were prepared by melt-molding method. Then, the antitumor activity and systemic drug distribution of the implants were tested in a K7M2 OS bearing mouse model. The scanning electron microscope images showed that DOX was uniformly dispersed in the polymer matrix. Both the in vitro and in vivo release profiles of implants are characterized by three-phase release. Implantation of DOX-loaded implants into tumors can inhibit tumor growth in a dose-dependent manner. The pharmacokinetic behavior shows that intratumor chemotherapy through implants has a much higher drug concentration in tumors than in normal tissues, which may be the reason for improving antitumor activity and reducing systemic side effects. In summary, the drug release of the implants prepared in this study is sustained and stable, which promotes long-term local accumulation of drugs in tumors, improves the efficacy of chemotherapy and has low toxicity to normal tissues. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1071-7544 1521-0464 10717544 |
| Relation: | https://doaj.org/toc/1071-7544; https://doaj.org/toc/1521-0464 |
| DOI: | 10.1080/10717544.2022.2032878 |
| URL الوصول: | https://doaj.org/article/59b94bf09000442b82d197dd8497cea4 |
| رقم الأكسشن: | edsdoj.59b94bf09000442b82d197dd8497cea4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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Full Text Finder | تدمد: | 10717544 15210464 |
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| DOI: | 10.1080/10717544.2022.2032878 |