دورية أكاديمية
Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses
| العنوان: | Effects of Paracetamol on Vascular Endothelial Growth Factor, Sclerostin and FETUIN-A in the Liver of Rat Fetuses |
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| المؤلفون: | Seher Yi̇lmaz, Yeşim Göçmen, Adem Tokpınar, İlyas Uçar, Şükrü Ateş, Seda Avni̇oğlu, Mehtap Ni̇sari̇ |
| المصدر: | Acta Medica Alanya, Vol 4, Iss 2, Pp 150-155 (2020) |
| بيانات النشر: | Alanya Alaaddin Keykubat University, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | vegf, paracetamol, liver, vegf-a, fetus, parasetamol, karaciğer, fetüs, Medicine |
| الوصف: | Aim: Paracetamol is widely used by important societal groups such as pregnant women and the elderly. Paracetamol, taken in high doses especially during pregnancy, causes liver failure. The aim of our study is to investigate the effects of paracetamol, which is widely used during pregnancy, on the fetal liver. Methods: In our study, five groups of randomly selected rats from 10 Wistar Albino rats (n=2) were formed as control group, 50 mg / kg paracetamol group, 125 mg / kg paracetamol group, 250 mg / kg paracetamol group and 500 mg / kg paracetamol group. Paracetamol by gavage was given to pregnant rats in specified doses. Fetuses were taken by cesarean on the 20th day of pregnancy (10 fetuses were taken from each group). The fetus livers were then taken for biochemical analysis. Biochemically, vascular endothelial growth factor A (VEGF-A), FETU-A (FETUIN-A) (α2-heremans-schmid glikoprotein) and Sclerostin (SOST) values were examined.Results: In this study, changes in liver hepatocyte cells are seen as the dose of paracetamol increases. Regular increase is observed in VEGF-A and FETU-A. SOST increased at a dose of 250 mg / kg and decreased in the group of 500 mg / kg paracetamol. (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English Turkish |
| تدمد: | 2587-0319 |
| Relation: | https://dergipark.org.tr/en/pub/medalanya/issue/56070/688286?publisher=alku; https://doaj.org/toc/2587-0319 |
| DOI: | 10.30565/medalanya.688286 |
| URL الوصول: | https://doaj.org/article/e59d06f6c77d4f3d9f430ee83586bc2f |
| رقم الأكسشن: | edsdoj.59d06f6c77d4f3d9f430ee83586bc2f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 25870319 |
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| DOI: | 10.30565/medalanya.688286 |