Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors

التفاصيل البيبلوغرافية
العنوان:	Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors
المؤلفون:	Melvin Pan, Christiane Zorbas, Maki Sugaya, Kensuke Ishiguro, Miki Kato, Miyuki Nishida, Hai-Feng Zhang, Marco M. Candeias, Akimitsu Okamoto, Takamasa Ishikawa, Tomoyoshi Soga, Hiroyuki Aburatani, Juro Sakai, Yoshihiro Matsumura, Tsutomu Suzuki, Christopher G. Proud, Denis L. J. Lafontaine, Tsuyoshi Osawa
المصدر:	Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
بيانات النشر:	Nature Portfolio, 2022.
سنة النشر:	2022
المجموعة:	LCC:Science
مصطلحات موضوعية:	Science
الوصف:	Small molecules that target RNA Polymerase I inhibit ribosome biogenesis to activate p53 through the nucleolar surveillance response pathway. Here, the authors show that p53 induction by ribosome stress is dependent on extracellular glutamine availability.
نوع الوثيقة:	article
وصف الملف:	electronic resource
اللغة:	English
تدمد:	2041-1723
Relation:	https://doaj.org/toc/2041-1723
DOI:	10.1038/s41467-022-31418-w
URL الوصول:	https://doaj.org/article/5a2c48021da748188909409721466a55
رقم الأكسشن:	edsdoj.5a2c48021da748188909409721466a55
قاعدة البيانات:	Directory of Open Access Journals

الوصف
تدمد:	20411723
DOI:	10.1038/s41467-022-31418-w