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Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior

التفاصيل البيبلوغرافية
العنوان: Nanofiber‐based glaucoma drainage implant improves surgical outcomes by modulating fibroblast behavior
المؤلفون: Aditya Josyula, Ann Mozzer, Julia Szeto, Youlim Ha, Nicole Richmond, Seung Woo Chung, Sri Vishnu Kiran Rompicharla, Janani Narayan, Samiksha Ramesh, Justin Hanes, Laura Ensign, Kunal Parikh, Ian Pitha
المصدر: Bioengineering & Translational Medicine, Vol 8, Iss 3, Pp n/a-n/a (2023)
بيانات النشر: Wiley, 2023.
سنة النشر: 2023
المجموعة: LCC:Chemical engineering
LCC:Biotechnology
LCC:Therapeutics. Pharmacology
مصطلحات موضوعية: fibrosis, glaucoma shunts, nanofibers, ocular biomaterials, Chemical engineering, TP155-156, Biotechnology, TP248.13-248.65, Therapeutics. Pharmacology, RM1-950
الوصف: Abstract Biomaterials are implanted in millions of individuals worldwide each year. Both naturally derived and synthetic biomaterials induce a foreign body reaction that often culminates in fibrotic encapsulation and reduced functional lifespan. In ophthalmology, glaucoma drainage implants (GDIs) are implanted in the eye to reduce intraocular pressure (IOP) in order to prevent glaucoma progression and vision loss. Despite recent efforts towards miniaturization and surface chemistry modification, clinically available GDIs are susceptible to high rates of fibrosis and surgical failure. Here, we describe the development of synthetic, nanofiber‐based GDIs with partially degradable inner cores. We evaluated GDIs with nanofiber or smooth surfaces to investigate the effect of surface topography on implant performance. We observed in vitro that nanofiber surfaces supported fibroblast integration and quiescence, even in the presence of pro‐fibrotic signals, compared to smooth surfaces. In rabbit eyes, GDIs with a nanofiber architecture were biocompatible, prevented hypotony, and provided a volumetric aqueous outflow comparable to commercially available GDIs, though with significantly reduced fibrotic encapsulation and expression of key fibrotic markers in the surrounding tissue. We propose that the physical cues provided by the surface of the nanofiber‐based GDIs mimic healthy extracellular matrix structure, mitigating fibroblast activation and potentially extending functional GDI lifespan.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2380-6761
Relation: https://doaj.org/toc/2380-6761
DOI: 10.1002/btm2.10487
URL الوصول: https://doaj.org/article/5a328a859a0b4ff6842687b015f31c2e
رقم الأكسشن: edsdoj.5a328a859a0b4ff6842687b015f31c2e
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:23806761
DOI:10.1002/btm2.10487