دورية أكاديمية
أعرض في EDS

Toxic-Induced Encephalopathy Following Chemsex in a Young HIV-Positive Male: A Complex Case of Acute Cognitive Impairment with Anterograde Amnesia and Behavioral Alterations

التفاصيل البيبلوغرافية
العنوان: Toxic-Induced Encephalopathy Following Chemsex in a Young HIV-Positive Male: A Complex Case of Acute Cognitive Impairment with Anterograde Amnesia and Behavioral Alterations
المؤلفون: Alexy Inciarte, Lorena de la Mora, Emilio Huaier-Arriazu, Berta Torres, Silvia Cañizares, Elizabeth Zamora, Montserrat Laguno, Ana Gonzalez-Cordón, Alberto Foncillas, Ivan Chivite, Júlia Calvo, Juan Ambrosioni, Esteban Martínez, Jose Luis Blanco, J. M. Miro, Maria Martinez-Rebollar, Josep Mallolas
المصدر: Infectious Diseases and Therapy, Vol 13, Iss 4, Pp 647-658 (2024)
بيانات النشر: Adis, Springer Healthcare, 2024.
سنة النشر: 2024
المجموعة: LCC:Infectious and parasitic diseases
مصطلحات موضوعية: Chemsex, Encephalopathy, Cognitive impairment, Anterograde amnesia, HIV, Infectious and parasitic diseases, RC109-216
الوصف: Abstract background A broadened clinical spectrum of concomitant complications emerges among the escalating incidence of substance use, particularly within the ‘chemsex’ context. This case exemplifies the profound neurotoxic repercussions and neurological risk of chemsex in a young HIV-positive male and addresses the multifaceted challenges of such evolving paradigms in substance utilization. Clinical finding After consuming cannabis, poppers, methamphetamine, and cocaine, a 28-year-old HIV-positive male exhibited significant neurological and cognitive impairment. The initial presentation included dysarthria and profound anterograde amnesia. Laboratory findings showed leukocytosis with a PCR of 3 mg/dl — elevated cerebrospinal fluid protein levels with no cells. Urine toxicology returned positive for cannabis and amphetamines. A brain CT scan revealed bilateral and symmetrical hippocampi and pale globes hypodensity, indicative of toxic-metabolic encephalopathy. MRI further identified lesions in the globus pallidus, cerebellum, and hippocampi. Following the detection of toxic encephalopathy, Initial neuropsychological was performed screening using the Montreal Cognitive Assessment (MoCA), which highlighted immediate memory deficits. An in-depth neuropsychological assessment conducted 3 weeks later included the Wechsler Adult Intelligence Scale-Fourth Edition (WAIS-IV), the Rey Auditory Verbal Learning Test (RAVLT), and tests for visuospatial skills, motor functions, and memory recall. The evaluations revealed pronounced anterograde amnesia, persistent long-term memory inconsistencies, and notable executive function challenges, detailed in Table 1. Conclusions The detailed analysis of this case underpins the severe neurological consequences that can manifest from heavy substance use. Comprehensive diagnostic evaluations, including neuroimaging and neuropsychological assessments, are crucial in elucidating the full spectrum of substance-induced cognitive impairments. There is an urgent need for enhanced public awareness and preventative measures, especially in the context of chemsex, to bring forth multifaceted health, social, and government implications that modern society must adeptly navigate.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2193-8229
2193-6382
Relation: https://doaj.org/toc/2193-8229; https://doaj.org/toc/2193-6382
DOI: 10.1007/s40121-024-00962-x
URL الوصول: https://doaj.org/article/5a41dd1b78d44b7aa9c4d65f56d3afc1
رقم الأكسشن: edsdoj.5a41dd1b78d44b7aa9c4d65f56d3afc1
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:21938229
21936382
DOI:10.1007/s40121-024-00962-x